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• W2337763744 abstract "Donor age is associated with cardiac allograft vasculopathy but whether plaque represents undetected donor plaque or increased immunogenicity and accelerated post-transplant plaque progression is unknown. 103 patients (pts) transplanted Mar 2010 - Dec 2012 with baseline (1 month post-transplant) and 1 yr intravascular ultrasound (IVUS) were included. Group 1 was defined as pts who received hearts from donors < 40 yr old, and Group 2, donors ≥ 40 yr old. Mean maximal intimal thickness (MIT), maximal intimal area (MIA), and percent atheroma volume (PAV) on baseline and 1 yr IVUS were compared. Progression of plaque between baseline and 1 yr, and rapid plaque progression (∆MIT 0.5 mm or ∆MIA 3.5 mm2) were compared. Mean recipient and donor age were 56.1 ± 12.7 and 33.3 ± 13.1 yr old, respectively. 65 (63.1%) received hearts from donors < 40 yr old (Group 1), and 38 (36.9%), from donors ≥ 40 yr old (Group 2). Recipient age was higher in Group 2 (52.9 ± 13.4 vs 61.7 ± 9.0 p<.001). Recipient and donor genders, high risk cytomegalovirus and sensitized status, antithymocyte globulin induction, post-transplant donor specific antibodies, and first yr mTOR inhibitor use were not significantly different between groups (all p>.10). Plaque on baseline IVUS was significantly higher in Group 2 (MIT: 0.36 ± 0.29 vs 0.71 ± 0.41 mm p<.001; MIA: 2.8 ± 1.7 vs 5.2 ± 3.0 mm2 p <.001; PAV: 9.9 ± 7.6 vs 15.9 vs 9.3 % p=.001), sustained at 1 yr (all p<.001). Every 10 yr increase in donor age, plaque on baseline IVUS increased by 0.14 mm MIT, 0.9 mm2 MIA, and 2.4% PAV by linear regression (all p<.001). Progression of plaque between baseline and 1 yr IVUS was not different between groups (MIT: 0.29 ± 0.30 vs 0.29 ± 0.25 mm p=.983; MIA: 1.6 ± 2.1 vs 1.9 ± 2.3 mm2 p=.631; PAV: 5.5 ± 6.4 vs 7.5 ± 7.7 % p=.192) nor was frequency of rapid plaque progression (12/65 vs 8/38 p=.799). Plaque progression was not associated with age by linear regression (all p>.10). Increasing donor age, although associated with modest increases in plaque burden noted on baseline IVUS, is not associated with accelerated plaque progression post-transplant. The implications of these findings for donor allograft selection warrant further investigations." @default.
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• W2337763744 date "2016-04-01" @default.
• W2337763744 modified "2023-09-23" @default.
• W2337763744 title "Cardiac Allograft Donor Age Is Associated with Increased Baseline Coronary Plaque Burden but Not with Its Progression as Assessed by Intravascular Ultrasound" @default.
• W2337763744 doi "https://doi.org/10.1016/j.healun.2016.01.563" @default.
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