Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337784664> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2337784664 abstract "Genome-wide association studies show strong evidence of association with endometriosis for markers on chromosome 1p36 spanning the potential candidate genes WNT4, CDC42 and LINC00339. WNT4 is involved in development of the uterus, and the expression of CDC42 and LINC00339 are altered in women with endometriosis. We conducted fine mapping to examine the role of coding variants in WNT4 and CDC42 and determine the key SNPs with strongest evidence of association in this region. We identified rare coding variants in WNT4 and CDC42 present only in endometriosis cases. The frequencies were low and cannot account for the common signal associated with increased risk of endometriosis. Genotypes for five common SNPs in the region of chromosome 1p36 show stronger association signals when compared with rs7521902 reported in published genome scans. Of these, three SNPs rs12404660, rs3820282, and rs55938609 were located in DNA sequences with potential functional roles including overlap with transcription factor binding sites for FOXA1, FOXA2, ESR1, and ESR2. Functional studies will be required to identify the gene or genes implicated in endometriosis risk." @default.
- W2337784664 created "2016-06-24" @default.
- W2337784664 creator A5008849838 @default.
- W2337784664 creator A5035995314 @default.
- W2337784664 creator A5037972668 @default.
- W2337784664 creator A5042709773 @default.
- W2337784664 creator A5043163204 @default.
- W2337784664 creator A5058010466 @default.
- W2337784664 creator A5059223431 @default.
- W2337784664 creator A5089710498 @default.
- W2337784664 date "2013-01-01" @default.
- W2337784664 modified "2023-09-23" @default.
- W2337784664 title "Fine mapping of variants associated with endometriosis in the WNT4 region on chromosome 1p36" @default.
- W2337784664 hasPublicationYear "2013" @default.
- W2337784664 type Work @default.
- W2337784664 sameAs 2337784664 @default.
- W2337784664 citedByCount "0" @default.
- W2337784664 crossrefType "journal-article" @default.
- W2337784664 hasAuthorship W2337784664A5008849838 @default.
- W2337784664 hasAuthorship W2337784664A5035995314 @default.
- W2337784664 hasAuthorship W2337784664A5037972668 @default.
- W2337784664 hasAuthorship W2337784664A5042709773 @default.
- W2337784664 hasAuthorship W2337784664A5043163204 @default.
- W2337784664 hasAuthorship W2337784664A5058010466 @default.
- W2337784664 hasAuthorship W2337784664A5059223431 @default.
- W2337784664 hasAuthorship W2337784664A5089710498 @default.
- W2337784664 hasConcept C104317684 @default.
- W2337784664 hasConcept C106208931 @default.
- W2337784664 hasConcept C126322002 @default.
- W2337784664 hasConcept C135763542 @default.
- W2337784664 hasConcept C153209595 @default.
- W2337784664 hasConcept C186413461 @default.
- W2337784664 hasConcept C2779522080 @default.
- W2337784664 hasConcept C54355233 @default.
- W2337784664 hasConcept C69991583 @default.
- W2337784664 hasConcept C71924100 @default.
- W2337784664 hasConcept C86803240 @default.
- W2337784664 hasConceptScore W2337784664C104317684 @default.
- W2337784664 hasConceptScore W2337784664C106208931 @default.
- W2337784664 hasConceptScore W2337784664C126322002 @default.
- W2337784664 hasConceptScore W2337784664C135763542 @default.
- W2337784664 hasConceptScore W2337784664C153209595 @default.
- W2337784664 hasConceptScore W2337784664C186413461 @default.
- W2337784664 hasConceptScore W2337784664C2779522080 @default.
- W2337784664 hasConceptScore W2337784664C54355233 @default.
- W2337784664 hasConceptScore W2337784664C69991583 @default.
- W2337784664 hasConceptScore W2337784664C71924100 @default.
- W2337784664 hasConceptScore W2337784664C86803240 @default.
- W2337784664 hasLocation W23377846641 @default.
- W2337784664 hasOpenAccess W2337784664 @default.
- W2337784664 hasPrimaryLocation W23377846641 @default.
- W2337784664 hasRelatedWork W1519041492 @default.
- W2337784664 hasRelatedWork W2014938327 @default.
- W2337784664 hasRelatedWork W2075786752 @default.
- W2337784664 hasRelatedWork W2078483392 @default.
- W2337784664 hasRelatedWork W2078698918 @default.
- W2337784664 hasRelatedWork W2119112300 @default.
- W2337784664 hasRelatedWork W2167629040 @default.
- W2337784664 hasRelatedWork W2201598970 @default.
- W2337784664 hasRelatedWork W2281144864 @default.
- W2337784664 hasRelatedWork W2326815424 @default.
- W2337784664 hasRelatedWork W2409762187 @default.
- W2337784664 hasRelatedWork W2502071203 @default.
- W2337784664 hasRelatedWork W2565505330 @default.
- W2337784664 hasRelatedWork W2890097051 @default.
- W2337784664 hasRelatedWork W2904864868 @default.
- W2337784664 hasRelatedWork W2953927480 @default.
- W2337784664 hasRelatedWork W3012765954 @default.
- W2337784664 hasRelatedWork W3013649707 @default.
- W2337784664 hasRelatedWork W3088983551 @default.
- W2337784664 hasRelatedWork W2182470619 @default.
- W2337784664 isParatext "false" @default.
- W2337784664 isRetracted "false" @default.
- W2337784664 magId "2337784664" @default.
- W2337784664 workType "article" @default.