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• W2337803710 endingPage "1069" @default.
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• W2337803710 abstract "We treated 17 patients who had Philadelphia-Chromosome-Positive chronic myelogenous leukemia (4 of whom had not received therapy and 13 of whom had been treated with hydroxyurea or busulfan for less than six months) with recombinant human interferon alpha-A (Roferon-A). The interferon was given as 5x106 units per square meter of body-surface area per day intramuscularly during induction therapy. Fourteen patients responded to the treatment, of whom 13 had a hematologic remission and 1 had a partial hematologic remission. The median number of white cells in those patients declined from 60.9x103to 3.4x103 per microliter, and the median number of platelets decreased from 476 x103 to 231 x103 per microliter. Among the five responding patients who had splenomegaly before treatment, the spleen size returned to normal in four and decreased by 75 percent in one, although it remained enlarged. Bone marrow cellularity declined from a median of 92.5 percent to a median of 57.5 percent. In six of the patients with hematologic remission, complete suppression of Philadelphia cells was observed on at least one examination. Of the 14 patients who responded, 11 have received the interferon therapy for 9 to 15 months. One patient relapsed during the treatment, and the treatment has been temporarily interrupted in two patients because of toxicity. These data are preliminary and will need further confirmation, but they suggest that recombinant human interferon alphaA is effective in inducing hematologic remission in most patients with benign-phase chronic myelogenous leukemia and in suppressing the Philadelphia chromosome in some of these patients. (N Engl J Med 1986; 314:1065–9.)" @default.
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• W2337803710 date "1986-04-24" @default.
• W2337803710 modified "2023-10-18" @default.
• W2337803710 title "Hematologic Remission and Cytogenetic Improvement Induced by Recombinant Human Interferon Alpha_Ain Chronic Myelogenous Leukemia" @default.
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• W2337803710 doi "https://doi.org/10.1056/nejm198604243141701" @default.
• W2337803710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3457264" @default.
• W2337803710 hasPublicationYear "1986" @default.
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