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- W2337807084 endingPage "75" @default.
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- W2337807084 abstract "Experimental in vitro and in vivo studies support the hypothesis that heat-treated, lyophilized Lactobacillus acidophilus LB cells and concentrated, neutralized spent culture medium conserve the variety of pharmacological, antimicrobial activities of the live probiotic strain against several infectious agents involved in well-established acute and persistent watery diarrhoea and gastritis. Heat-treated cells and heat-stable secreted molecules trigger multiple strain-specific activities explaining the therapeutic efficacy of L. acidophilus LB. This review discusses the current body of knowledge on the antimicrobial mechanisms of action exerted by L. acidophilus LB demonstrated in in vitro and in vivo experimental studies, and the evidence for the therapeutic efficacy of this anti-infectious biotherapeutic agent proved in randomized clinical trials for the treatment of acute and persistent watery diarrhoea associated with several intestinal infectious diseases in humans." @default.
- W2337807084 created "2016-06-24" @default.
- W2337807084 creator A5044316204 @default.
- W2337807084 date "2015-08-31" @default.
- W2337807084 modified "2023-10-16" @default.
- W2337807084 title "A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated <i>Lactobacillus</i> LB" @default.
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- W2337807084 doi "https://doi.org/10.1177/1756283x15602831" @default.
- W2337807084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4699271" @default.
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- W2337807084 hasPublicationYear "2015" @default.
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