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- W2337862243 abstract "Osteoporosis is a disabling skeletal disorder affecting 200 million people worldwide1. Presently, the main challenge is to develop new more effective drugs with reduced long-term side effects. Monitoring the interactions of diseased bone tissues with drugs is fundamental for osteoporosis drug development and screening. In vitro cytotoxicity assays represent the most commonly used approach for screening and validation of drug candidates in the early stage of drug discovery2. Most of these assays rely on two dimensional (2D) cell culture systems which do not allow for complex three dimensional (3D) spatial interactions (i.e. cell-cell and cell-extracellular matrix (ECM) interactions) typical in living bone and crucial for accurate results in toxicological testing3. Moreover, conventional 2D cytotoxicity screenings do not provide temporal information of the cellular response to drugs. Thus, there is a need for new and complementary 3D in vitro systems that can better mimic the in vivo microenvironment of bone architecture and enable in situ monitoring of bone cell response to osteoporosis drugs in real time." @default.
- W2337862243 created "2016-06-24" @default.
- W2337862243 creator A5061332627 @default.
- W2337862243 date "2016-01-01" @default.
- W2337862243 modified "2023-10-17" @default.
- W2337862243 title "Carbon Microelectrodes for Real Time Osteoporosis Drug Screenings" @default.
- W2337862243 doi "https://doi.org/10.1149/ma2016-01/7/606" @default.
- W2337862243 hasPublicationYear "2016" @default.
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