Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337897129> ?p ?o ?g. }
- W2337897129 endingPage "5712" @default.
- W2337897129 startingPage "5705" @default.
- W2337897129 abstract "The outermost layer of the mammalian skin, the epidermis, forms a protective barrier against pathogenic microbes and tissue dehydration. This barrier is formed and maintained by complex genetic networks that connect cellular differentiation processes, enzymatic activities and cellular junctions. Disruption in these networks affects the balance between keratinocyte proliferation and differentiation resulting in barrier function impairment, epidermal hyperproliferation and in some cases, squamous cell carcinoma (SCC). Recent studies in wound-induced inflammation-mediated cancers in mice have identified dysregulation of core barrier components as tumor drivers. We therefore propose a hypothesis in which loss of key barrier genes, induce barrier dysfunction, and promote inflammation-driven epidermal hyperplasia and carcinogenesis over time. This emerging vision suggests that under specific genetic circumstances, localized barrier impairment could be considered as a hallmark of initiating lesions in epidermal SCC." @default.
- W2337897129 created "2016-06-24" @default.
- W2337897129 creator A5013957353 @default.
- W2337897129 creator A5054259850 @default.
- W2337897129 creator A5059629859 @default.
- W2337897129 date "2016-04-04" @default.
- W2337897129 modified "2023-09-25" @default.
- W2337897129 title "The role of barrier genes in epidermal malignancy" @default.
- W2337897129 cites W1513329088 @default.
- W2337897129 cites W1534987406 @default.
- W2337897129 cites W1537074337 @default.
- W2337897129 cites W1822696893 @default.
- W2337897129 cites W1843364511 @default.
- W2337897129 cites W1920167267 @default.
- W2337897129 cites W1958497199 @default.
- W2337897129 cites W1963810456 @default.
- W2337897129 cites W1963892864 @default.
- W2337897129 cites W1965038309 @default.
- W2337897129 cites W1965235767 @default.
- W2337897129 cites W1969597856 @default.
- W2337897129 cites W1971216237 @default.
- W2337897129 cites W1971670935 @default.
- W2337897129 cites W1971896241 @default.
- W2337897129 cites W1973705683 @default.
- W2337897129 cites W1976411908 @default.
- W2337897129 cites W1980960936 @default.
- W2337897129 cites W1981726745 @default.
- W2337897129 cites W1982540283 @default.
- W2337897129 cites W1986301169 @default.
- W2337897129 cites W1990827000 @default.
- W2337897129 cites W1991863313 @default.
- W2337897129 cites W1997226073 @default.
- W2337897129 cites W2000517600 @default.
- W2337897129 cites W2000539977 @default.
- W2337897129 cites W2004337545 @default.
- W2337897129 cites W2006419043 @default.
- W2337897129 cites W2006611087 @default.
- W2337897129 cites W2007146099 @default.
- W2337897129 cites W2016704574 @default.
- W2337897129 cites W2017009650 @default.
- W2337897129 cites W2020459118 @default.
- W2337897129 cites W2021302907 @default.
- W2337897129 cites W2022012328 @default.
- W2337897129 cites W2023332224 @default.
- W2337897129 cites W2024460791 @default.
- W2337897129 cites W2024815096 @default.
- W2337897129 cites W2026151319 @default.
- W2337897129 cites W2028689768 @default.
- W2337897129 cites W2029427811 @default.
- W2337897129 cites W2031721857 @default.
- W2337897129 cites W2034131665 @default.
- W2337897129 cites W2035793907 @default.
- W2337897129 cites W2039501234 @default.
- W2337897129 cites W2041677910 @default.
- W2337897129 cites W2043180208 @default.
- W2337897129 cites W2047361342 @default.
- W2337897129 cites W2051048707 @default.
- W2337897129 cites W2054273558 @default.
- W2337897129 cites W2058497055 @default.
- W2337897129 cites W2060081775 @default.
- W2337897129 cites W2064782859 @default.
- W2337897129 cites W2067018261 @default.
- W2337897129 cites W2067772036 @default.
- W2337897129 cites W2070081201 @default.
- W2337897129 cites W2071918867 @default.
- W2337897129 cites W2073629026 @default.
- W2337897129 cites W2076320536 @default.
- W2337897129 cites W2078928912 @default.
- W2337897129 cites W2080914248 @default.
- W2337897129 cites W2081470147 @default.
- W2337897129 cites W2082710846 @default.
- W2337897129 cites W2084715486 @default.
- W2337897129 cites W2087527298 @default.
- W2337897129 cites W2091605033 @default.
- W2337897129 cites W2091776694 @default.
- W2337897129 cites W2093221417 @default.
- W2337897129 cites W2093943502 @default.
- W2337897129 cites W2096885650 @default.
- W2337897129 cites W2102395429 @default.
- W2337897129 cites W2105241867 @default.
- W2337897129 cites W2107638340 @default.
- W2337897129 cites W2110838173 @default.
- W2337897129 cites W2112718635 @default.
- W2337897129 cites W2114950999 @default.
- W2337897129 cites W2118278569 @default.
- W2337897129 cites W2122416344 @default.
- W2337897129 cites W2124580184 @default.
- W2337897129 cites W2125956695 @default.
- W2337897129 cites W2126973239 @default.
- W2337897129 cites W2127331850 @default.
- W2337897129 cites W2128334329 @default.
- W2337897129 cites W2128492601 @default.
- W2337897129 cites W2129179796 @default.
- W2337897129 cites W2130332340 @default.
- W2337897129 cites W2132024007 @default.
- W2337897129 cites W2134537843 @default.
- W2337897129 cites W2138660441 @default.
- W2337897129 cites W2139960013 @default.