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- W2337900970 abstract "MicroRNA (miR) 429 has been shown to inhibit epithelial-to-mesenchymal transition (EMT) and promote mesenchymal-to-epithelial transition (MET). The present study determined whether miR429 participated in angiotensin (ANG) II-induced transdifferentiation and consequent fibrogenesis in renal cells. In NRK-52E cells, a rat proximal tubular cell line, incubation of ANG II (1 nM) for 24 h significantly reduced the level of mir429 by 60% and meanwhile increased the protein levels of mechansymal markers α-smooth muscle actin (α-SMA) and fibroblast-specific protein (FSP)-1 by 3 fold and decreased epithelial marker E-cadherin by 60%. In cells transfected with plasmids expressing mir429, ANG II-induced changes in the above markers were abolished. Male Sprague-Dawley rats were treated with chronic infusion of vehicle, ANG II (200 ng/kg/min) or ANG II + intrarenal transfection of lentivirus expressing mir429 for 12 days. The levels of mir429 in the kidneys were reduced by 75% in ANG II-treated rats. The protein levels of α-SMA, FSP-1 and collagen I/III were much higher and E-cadherin lower in the kidneys in ANG II-treated rats than that in control. These changes were reversed in ANG II + mir429-treated rats. The urinary albumin were 0.9±0.36 mg/Kg/24h in control, 2.8±0.28 mg/Kg/24h in ANG II-treated and 1.2± 0.27 mg/Kg/24h in ANG II+mir429-treated rats, respectively, at the end of experiment. There was no difference in the increases of blood pressure between ANG II- and ANG II+mir429- treated rats. These data suggested that ANG II produces transdifferentiation and fibrogenesis in renal cells via inhibiting mir429 expression and that miR429 protects against ANG II-induced kidney damage. (Grant supports: NIH HL89563 and HL106042)" @default.
- W2337900970 created "2016-06-24" @default.
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- W2337900970 date "2015-04-01" @default.
- W2337900970 modified "2023-10-16" @default.
- W2337900970 title "Inhibition of MicroRNA‐429 Expression Mediates Angiotensin II‐induced Kidney Damages in Rats" @default.
- W2337900970 doi "https://doi.org/10.1096/fasebj.29.1_supplement.960.21" @default.
- W2337900970 hasPublicationYear "2015" @default.
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