Matches in SemOpenAlex for { <https://semopenalex.org/work/W2337908032> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2337908032 abstract "Mesenchymal stem cells (MSCs) derived from bone marrow are plural-potent stem cells with immune regulatory functions. We aimed to evaluate role of FcγRIIB in the regulation of bone marrow-derived MSC function. MSCs were prepared from mouse bone marrow derived from wild-type (WT) or FcγRIIB-deficient (FcγRIIB-/-) mice. MSCs were co-cultured with bone marrow-derived dendritic cells (BMDCs), and BMDC maturation and function were evaluated by flow cytometric analysis and carboxyfluorescein succinimidyl ester-labeled OT-II T-cell addition. An acute asthma model was established by aeresol ovalbumin challenge in mice. Mice received WT or FcγRIIB-/- MSC therapy. Lung function was evaluated by histological examination and cytokine production measurement. mRNA and protein expression levels of target genes were examined by real-time quantitative polymerase chain reactionor western blotting. We found that MSCs derived from bone marrow exhibit a high level of FcγRIIB expression. FcγRIIB deficiency impaired the suppressive function of MSCs, as FcγRIIB deficiency efficiently reversed the inhibitory effect of MSCs on BMDC maturation and function. Additionally, FcγRIIB-/-MSCs were less potent at suppressing asthma in model mice, possibly through reduced expression of Smad2, Smad3, Cox-2, and prostaglandin E2 in FcγRIIB-/-MSCs. FcγRIIB might play an essential role in regulating the inhibitory effects of MSCs derived from bone marrow." @default.
- W2337908032 created "2016-06-24" @default.
- W2337908032 creator A5005726726 @default.
- W2337908032 creator A5014924460 @default.
- W2337908032 creator A5017102094 @default.
- W2337908032 creator A5019315614 @default.
- W2337908032 creator A5045102265 @default.
- W2337908032 creator A5058420472 @default.
- W2337908032 creator A5060996227 @default.
- W2337908032 creator A5074483257 @default.
- W2337908032 creator A5074490226 @default.
- W2337908032 creator A5090004022 @default.
- W2337908032 date "2016-01-01" @default.
- W2337908032 modified "2023-10-16" @default.
- W2337908032 title "Functional Role of FcγRIIB in the Regulation of Mesenchymal Stem Cell Function" @default.
- W2337908032 cites W1973112307 @default.
- W2337908032 cites W1979043688 @default.
- W2337908032 cites W1982023994 @default.
- W2337908032 cites W1983351186 @default.
- W2337908032 cites W2000115558 @default.
- W2337908032 cites W2007104941 @default.
- W2337908032 cites W2009726358 @default.
- W2337908032 cites W2025826180 @default.
- W2337908032 cites W2048068545 @default.
- W2337908032 cites W2054717462 @default.
- W2337908032 cites W2056879158 @default.
- W2337908032 cites W2062244945 @default.
- W2337908032 cites W2065869173 @default.
- W2337908032 cites W2075901113 @default.
- W2337908032 cites W2098893605 @default.
- W2337908032 cites W2105151699 @default.
- W2337908032 cites W2117240723 @default.
- W2337908032 cites W2153048580 @default.
- W2337908032 cites W2160330354 @default.
- W2337908032 cites W2162699339 @default.
- W2337908032 cites W2169521192 @default.
- W2337908032 cites W2442542770 @default.
- W2337908032 doi "https://doi.org/10.7150/ijms.13649" @default.
- W2337908032 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4764783" @default.
- W2337908032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26941575" @default.
- W2337908032 hasPublicationYear "2016" @default.
- W2337908032 type Work @default.
- W2337908032 sameAs 2337908032 @default.
- W2337908032 citedByCount "1" @default.
- W2337908032 countsByYear W23379080322018 @default.
- W2337908032 crossrefType "journal-article" @default.
- W2337908032 hasAuthorship W2337908032A5005726726 @default.
- W2337908032 hasAuthorship W2337908032A5014924460 @default.
- W2337908032 hasAuthorship W2337908032A5017102094 @default.
- W2337908032 hasAuthorship W2337908032A5019315614 @default.
- W2337908032 hasAuthorship W2337908032A5045102265 @default.
- W2337908032 hasAuthorship W2337908032A5058420472 @default.
- W2337908032 hasAuthorship W2337908032A5060996227 @default.
- W2337908032 hasAuthorship W2337908032A5074483257 @default.
- W2337908032 hasAuthorship W2337908032A5074490226 @default.
- W2337908032 hasAuthorship W2337908032A5090004022 @default.
- W2337908032 hasBestOaLocation W23379080321 @default.
- W2337908032 hasConcept C185592680 @default.
- W2337908032 hasConcept C198826908 @default.
- W2337908032 hasConcept C203014093 @default.
- W2337908032 hasConcept C2776946954 @default.
- W2337908032 hasConcept C2780007613 @default.
- W2337908032 hasConcept C28328180 @default.
- W2337908032 hasConcept C86803240 @default.
- W2337908032 hasConcept C8891405 @default.
- W2337908032 hasConcept C95444343 @default.
- W2337908032 hasConceptScore W2337908032C185592680 @default.
- W2337908032 hasConceptScore W2337908032C198826908 @default.
- W2337908032 hasConceptScore W2337908032C203014093 @default.
- W2337908032 hasConceptScore W2337908032C2776946954 @default.
- W2337908032 hasConceptScore W2337908032C2780007613 @default.
- W2337908032 hasConceptScore W2337908032C28328180 @default.
- W2337908032 hasConceptScore W2337908032C86803240 @default.
- W2337908032 hasConceptScore W2337908032C8891405 @default.
- W2337908032 hasConceptScore W2337908032C95444343 @default.
- W2337908032 hasLocation W23379080321 @default.
- W2337908032 hasLocation W23379080322 @default.
- W2337908032 hasLocation W23379080323 @default.
- W2337908032 hasLocation W23379080324 @default.
- W2337908032 hasOpenAccess W2337908032 @default.
- W2337908032 hasPrimaryLocation W23379080321 @default.
- W2337908032 hasRelatedWork W2038477076 @default.
- W2337908032 hasRelatedWork W2040079807 @default.
- W2337908032 hasRelatedWork W2080873721 @default.
- W2337908032 hasRelatedWork W2104031957 @default.
- W2337908032 hasRelatedWork W2105666819 @default.
- W2337908032 hasRelatedWork W2145070315 @default.
- W2337908032 hasRelatedWork W2171075518 @default.
- W2337908032 hasRelatedWork W2508902805 @default.
- W2337908032 hasRelatedWork W3120507315 @default.
- W2337908032 hasRelatedWork W4225365553 @default.
- W2337908032 isParatext "false" @default.
- W2337908032 isRetracted "false" @default.
- W2337908032 magId "2337908032" @default.
- W2337908032 workType "article" @default.