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- W2337911855 abstract "Microspheres of pancreatin should empty from the stomachs of patients with pancreatic insufficiency as fast as food. The present study was undertaken in 26 healthy subjects to identify the size of spheres that would empty from the stomach with food and to determine whether different meals alter this size. Spheres of predefined sizes were labeled with *13Yn or ggmTc. Using a y-camera, we studied the concurrent gastric emptying of spheres labeled with 113mIn and of chicken liver labeled with ggmTc in 100-g 154kcal or 420-g, 91%kcal meals, or the concurrent emptying of l-mm vs. larger spheres. One-millimeter spheres emptied consistently (p < 0.01, paired f-test) faster than 2.4- or 3.2-mm spheres when ingested together with either the 420- or 100-g meals. Thus, in the l-3-mm range of diameters, sphere size was a more important determinant of sphere emptying than meal size. Statistical analyses indicated that spheres 1.4 f 0.3 mm in diameter with a density of 1 empty at the same rate as ““Tc-liver. Our data indicate some commercially marketed microspheres of pancreatin will empty too slowly to be effective in digestion of food." @default.
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- W2337911855 date "1988-01-01" @default.
- W2337911855 modified "2023-09-27" @default.
- W2337911855 title "Human Postprandial Gastric l-3-Millimeter Spheres Emptying of" @default.
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