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• W2337952892 abstract "During embryogenesis the sea urchin early pluteus larva differentiates 40-50 neurons marked by expression of the pan-neural marker synaptotagmin B (SynB) distributed along the ciliary band, in the apical plate and pharyngeal endoderm, and 4-6 serotonergic neurons confined to the apical plate. Development of all neurons has been shown to depend on the function of Six3. Using a combination of molecular screens and tests of gene function by morpholino-mediated knockdown, we identified SoxC and Brn1/2/4, which function sequentially in the neurogenic regulatory pathway and also are required for differentiation of all neurons. Mis/over-expression of Brn1/2/4 at low dose caused an increase in the number of serotonin-expressing cells and at higher dose converted most of the embryo to a neurogenic epithelial sphere expressing the hnf6 ciliary band marker. A third factor, Z167, was shown to work downstream of the Six3 and SoxC core factors and to define a branch specific for differentiation of serotonergic neurons. These results provide a framework for building a gene regulatory network for neurogenesis in the sea urchin embryo." @default.
• W2337952892 created "2016-06-24" @default.
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• W2337952892 date "2015-01-01" @default.
• W2337952892 modified "2023-10-05" @default.
• W2337952892 title "Neurogenic gene regulatory pathways in the sea urchin embryo" @default.
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• W2337952892 doi "https://doi.org/10.1242/dev.125989" @default.
• W2337952892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4725339" @default.
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• W2337952892 hasPublicationYear "2015" @default.
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