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• W2337973514 abstract "This paper aimed to assess the physiological effects of p53 on glucose homeostasis in vivo.A recombinant adenoviral p53 (rAd-p53) vector was administered to insulin-resistant diabetic mice. Intraperitoneal glucose tolerance test was performed in all groups of mice. Changes in fasting blood glucose, serum triglycerides, C-peptide, and insulin concentrations in treated and untreated mice were measured. Analyses of the target genes related to glucose metabolism were performed.Treatment with the rAd-p53 improved glucose control in a dose- and time-dependent manner and lowered significantly the fasting blood glucose, the serum triglycerides, and improved tolerance test of glucose as compared to control. Lowered blood glucose was associated with up-regulation of genes in the glycogenesis pathways, and down-regulation of genes in the gluconeogenesis pathways in the liver. Overexpressions of GLUT2, GK, PPAR-γ, and insulin receptor precursor were also observed in the liver and the pancreas of treated animals.Activation of p53-mediated glucose metabolism led to insulin-like antidiabetic effect in the mouse model especially by changing hepatic insulin sensitivity in the diabetic mouse model." @default.
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• W2337973514 date "2016-08-01" @default.
• W2337973514 modified "2023-09-26" @default.
• W2337973514 title "Overexpression of p53 Improves Blood Glucose Control in an Insulin Resistant Diabetic Mouse Model" @default.
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• W2337973514 doi "https://doi.org/10.1097/mpa.0000000000000637" @default.
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