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- W2337994704 abstract "Current treatment of systemic sclerosis.Part II. Vascular and antifibrotic treatmentSicinska J., Rudnicka L.Central Clinical Hospital of the Ministry of Interior and Administra-tion, Warsaw, Poland, Department of Dermatology,e-mail: justyna.sicinska@cskmswia.plMicrovascular abnormalities and fibrosis are important targets of the-rapy in systemic sclerosis (scleroderma). Calcium channel blockers,ACE inhibitors, sartans, phosphodiesterase-5 inhibitors and seroto-nin re-uptake blockers are used for Raynaud’s phenomenon. Intra-venous prostanoids (alprostadil, iloprost, epoprostenol, treprostinil)and endothelin receptor antagonists (bosentan, sitaxsentan, ambri-sentan) show efficacy in treatment of pulmonary hypertension anddistal ischemia. Succesfull treatment of digital ulcers secondary tosystemic sclerosis was possible with sildenafil and bosentan. A pla-telet gel is currently in clinical trials for scleroderma-related digitalulcers. Several drugs, which directly reduce excessive production ofcollagens and other connective tissue proteins have been applied insystemic sclerosis. These include interferon gamma, d-penicillami-ne, kolchichicine, calcitriol, and imanitib. However, so far, strategiesto control fibrosis by directly reducing excessive connective tissueproduction have been disappointing in controlled studies.Key words: bosentan, sildenafil, prostaglandins, sclerodema, sys-temic sclerosis, therapyPol. Merk. Lek., 2008, XXV, 146, 196" @default.
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- W2337994704 date "2008-01-01" @default.
- W2337994704 modified "2023-09-27" @default.
- W2337994704 title "Współczesne metody leczenia twardziny układowej. Część II. Leki wpływające na zaburzenia krążenia obwodowego i włóknienie" @default.
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