Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338021849> ?p ?o ?g. }
- W2338021849 endingPage "556" @default.
- W2338021849 startingPage "547" @default.
- W2338021849 abstract "The chemotherapeutic agent doxorubicin causes cardiac injury in a subset of cancer patients. This variable clinical response to doxorubicin treatment can be recapitulated in vitro by using cardiomyocytes derived from patient-specific induced pluripotent cells. Doxorubicin is an anthracycline chemotherapy agent effective in treating a wide range of malignancies, but it causes a dose-related cardiotoxicity that can lead to heart failure in a subset of patients. At present, it is not possible to predict which patients will be affected by doxorubicin-induced cardiotoxicity (DIC). Here we demonstrate that patient-specific human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) can recapitulate the predilection to DIC of individual patients at the cellular level. hiPSC-CMs derived from individuals with breast cancer who experienced DIC were consistently more sensitive to doxorubicin toxicity than hiPSC-CMs from patients who did not experience DIC, with decreased cell viability, impaired mitochondrial and metabolic function, impaired calcium handling, decreased antioxidant pathway activity, and increased reactive oxygen species production. Taken together, our data indicate that hiPSC-CMs are a suitable platform to identify and characterize the genetic basis and molecular mechanisms of DIC." @default.
- W2338021849 created "2016-06-24" @default.
- W2338021849 creator A5007131364 @default.
- W2338021849 creator A5010445417 @default.
- W2338021849 creator A5011447976 @default.
- W2338021849 creator A5012727469 @default.
- W2338021849 creator A5016780098 @default.
- W2338021849 creator A5024387589 @default.
- W2338021849 creator A5042036530 @default.
- W2338021849 creator A5046095673 @default.
- W2338021849 creator A5047561254 @default.
- W2338021849 creator A5048125824 @default.
- W2338021849 creator A5052487618 @default.
- W2338021849 creator A5057606234 @default.
- W2338021849 creator A5061773218 @default.
- W2338021849 creator A5067004024 @default.
- W2338021849 creator A5070508954 @default.
- W2338021849 creator A5081185233 @default.
- W2338021849 creator A5091649334 @default.
- W2338021849 date "2016-04-18" @default.
- W2338021849 modified "2023-10-10" @default.
- W2338021849 title "Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity" @default.
- W2338021849 cites W1492360552 @default.
- W2338021849 cites W1512691487 @default.
- W2338021849 cites W153782837 @default.
- W2338021849 cites W1669763518 @default.
- W2338021849 cites W1730021373 @default.
- W2338021849 cites W1828224642 @default.
- W2338021849 cites W1833330468 @default.
- W2338021849 cites W1906645663 @default.
- W2338021849 cites W1920198420 @default.
- W2338021849 cites W1964578632 @default.
- W2338021849 cites W1967144398 @default.
- W2338021849 cites W1976942938 @default.
- W2338021849 cites W1982718408 @default.
- W2338021849 cites W1990864926 @default.
- W2338021849 cites W1994735427 @default.
- W2338021849 cites W2001554877 @default.
- W2338021849 cites W2002708055 @default.
- W2338021849 cites W2008572994 @default.
- W2338021849 cites W2011893748 @default.
- W2338021849 cites W2021341670 @default.
- W2338021849 cites W2023175623 @default.
- W2338021849 cites W2026117523 @default.
- W2338021849 cites W2036079369 @default.
- W2338021849 cites W2036536995 @default.
- W2338021849 cites W2042091538 @default.
- W2338021849 cites W2044101767 @default.
- W2338021849 cites W2045626197 @default.
- W2338021849 cites W2050168274 @default.
- W2338021849 cites W2059487482 @default.
- W2338021849 cites W2066390373 @default.
- W2338021849 cites W2074744546 @default.
- W2338021849 cites W2078202582 @default.
- W2338021849 cites W2083369014 @default.
- W2338021849 cites W2083680622 @default.
- W2338021849 cites W2084304742 @default.
- W2338021849 cites W2086943348 @default.
- W2338021849 cites W2088152986 @default.
- W2338021849 cites W2091895125 @default.
- W2338021849 cites W2092984629 @default.
- W2338021849 cites W2094906575 @default.
- W2338021849 cites W2095041841 @default.
- W2338021849 cites W2097388785 @default.
- W2338021849 cites W2099814384 @default.
- W2338021849 cites W2100305481 @default.
- W2338021849 cites W2102785500 @default.
- W2338021849 cites W2102946330 @default.
- W2338021849 cites W2106578986 @default.
- W2338021849 cites W2107556826 @default.
- W2338021849 cites W2108234281 @default.
- W2338021849 cites W2108694827 @default.
- W2338021849 cites W2111426313 @default.
- W2338021849 cites W2112885253 @default.
- W2338021849 cites W2114380943 @default.
- W2338021849 cites W2118258530 @default.
- W2338021849 cites W2120024428 @default.
- W2338021849 cites W2120865735 @default.
- W2338021849 cites W2120989585 @default.
- W2338021849 cites W2123649031 @default.
- W2338021849 cites W2125512776 @default.
- W2338021849 cites W2134189998 @default.
- W2338021849 cites W2136651394 @default.
- W2338021849 cites W2140182328 @default.
- W2338021849 cites W2140729960 @default.
- W2338021849 cites W2145795438 @default.
- W2338021849 cites W2146606376 @default.
- W2338021849 cites W2147389335 @default.
- W2338021849 cites W2157134137 @default.
- W2338021849 cites W2157806784 @default.
- W2338021849 cites W2162509257 @default.
- W2338021849 cites W2165646374 @default.
- W2338021849 cites W2170989872 @default.
- W2338021849 cites W2172186675 @default.
- W2338021849 cites W2193321641 @default.
- W2338021849 cites W2227148039 @default.
- W2338021849 cites W2249991663 @default.
- W2338021849 cites W2317055602 @default.