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- W2338062425 abstract "The unexplained association of unusually large maintenance doses of digoxin and low serum digoxin concentrations in several patients prompted a study of the biologic availability of various digoxin products recently available for use on the wards of a New York City municipal hospital. In crossover studies in which 0.5 mg of digoxin was administered orally to normal volunteers, marked differences in serum digoxin levels achieved over a five-hour period were demonstrated. With one product peak serum levels were seven times those obtained with another. Significant variation between different lots prepared by a single manufacturer was also observed. Evidence of biologic as well as chemical equivalency of digoxin products for use in man should be required." @default.
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- W2338062425 date "1971-12-09" @default.
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- W2338062425 title "Variation in Biologic Availability of Digoxin from Four Preparations" @default.
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- W2338062425 doi "https://doi.org/10.1056/nejm197112092852403" @default.
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