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• W2338094613 abstract "28 In Saccharomyces cerevisiae, the Ras/cAMP/PKA pathway is a nutrient-sensitive signaling cascade 29 that regulates vegetative growth, carbohydrate metabolism and entry into meiosis. How this 30 pathway controls later steps of meiotic development is largely unknown. Here, we have analyzed 31 the role of the Ras/cAMP/PKA pathway on spore formation by meiosis-specific manipulation of 32 Ras and PKA or by disturbance of cAMP production. We found that regulation of spore formation 33 by acetate takes place after commitment to meiosis and depends on PKA and appropriate A kinase 34 activation by Ras/Cyr1 adenylyl cyclase, but not by activation through the Gpa2/Gpr1 branch. We 35 further discovered that spore formation is regulated by carbon dioxide/bicarbonate, and analysis of 36 mutants defective in acetate transport (ady2∆) or carbonic anhydrase (nce103∆) provided evidence 37 that these metabolites are involved in connecting the nutritional state of the meiotic cell to spore 38 number control. Finally, we observed that the potential PKA target Ady1 is required for the proper 39 localization of the meiotic plaque proteins Mpc70 and Spo74 at spindle pole bodies and for the 40 ability of these proteins to initiate spore formation. Overall, our investigation suggests that the 41 Ras/cAMP/PKA pathway plays a crucial role in regulation of spore formation by acetate and 42 indicates that control of meiotic development by this signaling cascade takes places at several steps 43 and is more complex than previously anticipated. 44 45" @default.
• W2338094613 created "2016-06-24" @default.
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• W2338094613 date "2012-01-01" @default.
• W2338094613 modified "2023-09-27" @default.
• W2338094613 title "Acetate regulation of spore formation is under control of the Ras/cAMP/PKA" @default.
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• W2338094613 hasPublicationYear "2012" @default.
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