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- W2338147971 abstract "Purpose: The objective of this phase II study was to assess the clinical antitumor activity and toxicities of docetaxel and cisplatin chem otherapy, in patients with locally advanced and m etastatic, recurrent squam ous cell carcinom as of the head and neck (SCCHN). Materials and Methods: All eligible patients with locally advanced and metastatic, recurrent SCCHN had received two courses of chemotherapy followed by repeated head and neck examinations and com puted tom ography. Patients who had received prior chemotherapy with taxanes were ineligible. If the patients achieved a response (either CR or PR), they received one m ore course of chem otherapy prior to undergoing definitive local treatm ent. The com bination chemotherapy consisted of docetaxel, 70 m g/m , and cisplatin, 75 m g/m , on day 1, with the cycles repeated every 3 4 weeks. Results: All 32 patients were assessable for response and toxicity analyses. The m ost com mon grade 3/4 adverse event was neutropenia, which occurred in 11% of cases. No febrile neutropenia was noticed. The other grade 3/4 adverse events included: anem ia (2% ) and stomatitis (3%). The response rate in patients with locally advanced cancer was 19/21 (90%). Fifteen patients (71%) achieved a CR and 4 (19% ) a PR. Out of the 4 patients presenting with a distant metastatic disease, 1 each achieved CR and PR, with 2 stable disease (SD). Out of the 7 patients with a recurrence at a distant site, 1 each achieved PR and SD, and 5 (71% ) had a progression of the disease (PD). The overall response rate was 22/32 (69%). Conclusion: Docetaxel plus cisplatin is an effective regimen with an acceptable toxicity profile. This regimen m ay offer high antitumor activity on short outpatient adm inistration, with a low incidence of severe toxicity. (Cancer Research and Treatm ent 2003;35:261-266)" @default.
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- W2338147971 date "2003-01-01" @default.
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- W2338147971 title "D ocetaxel and C isplatin C om bination C hem otherapy in P atients w ith Squam ous C ell C arcinom as of the H ead and N eck" @default.
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