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- W2338163090 abstract "<i>Background:</i> During the last two decades, research about GATA-3, Ki-67, p53 expressions have been done, but it is still a debate on their use in predicting breast cancer patients’ prognosis and survival rate. Expressions of GATA-3 decreased with increasing of histopathology grading of breast cancer and increase with decrease of histopathology grading of breast cancer. The level expression of Ki-67 has a positive relation with breast cancer histopathology grading. p53 has no correlation with high grade differentiation of breast cancer. p53 is a transcription factor which is activated as a part of cellular stress response that can regulate genes’ cellular process, including apoptosis and senescence. <i>Aim:</i> To determine correlation between expressions of GATA 3, Ki-67 and p53 with histopathology grading of breast cancer in Makassar, Indonesia. <i>Methods:</i> Antibody monoclonal GATA 3, Ki-67 and p53 on the nucleus cell were detected with immunohistochemistry method. The positive and negative expressions of GATA 3, Ki-67 and p53 were assessed using scoring system according to the proportion of positive cell and coloring intensities. <i>Results:</i> There is no correlation between the higher positive expression ofp53 and higher expression of histopathology grading of breast cancer (<i>P</i> = 0.089). While Ki-67 had positive association with higher grade malignancy (<i>P</i> = 0.03). However, there was no association between GATA-3 expression and histopathology grading. <i>Conclusion:</i> In our research we found there is no correlation between higher expression of p53 and low expression of GATA-3 with higher histopathology grading of breast cancer. High expression of Ki-67 have significantly statistic analysis with high expression of histopathology grading of mammary cancer." @default.
- W2338163090 created "2016-06-24" @default.
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- W2338163090 date "2016-01-01" @default.
- W2338163090 modified "2023-09-25" @default.
- W2338163090 title "Correlation Between <i>GATA-3</i>, <i>Ki67</i> and p53 Expressions to Histopathology Grading of Breast Cancer in Makassar, Indonesia" @default.
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- W2338163090 doi "https://doi.org/10.11648/j.crj.20160403.11" @default.
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