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- W2338194278 abstract "Introduction: Among the vasopressor Dopamine and Norepinephrine are most widely used. Till date there is a continuing controversy about whether one agent is superior to the other. Method: This was a prospective randomized trial conducted in a 12 bedded ICU at a tertiary care center from 1st August 2014 to 31stAugust 2015 a total of 1046 patients requiring a vasopressor were randomized, received either Dopamine or Norepinephrine as the first drug of choice to maintain target Mean arterial Pressure.The outcome of the trial at the end was the rate of death at 28 days. Further at the end we would also see the adverse events due to drug and mortality during ICU stay and number of days stay in the ICU and hospital. Result: In the study 521 were assigned to receive Dopamine and 525 were assigned to receive Norepinephrine. The 28 days mortality in Dopamine arm was 51.6% (269/521) and in Norepinephrine arm was 47.2 % (248/525). Arrhythmias was seen more in Dopamine arm (26.12%) compared to Norepinephrine arm (14.40%). Mortality during ICU stay was more in patients who receive Dopamine (51.6%) then to patients who receive Norepinephrin (46.1%) although this difference was not statically significant (P-value >0.05). Further the length of stay in ICU and in hospital was more in patients who received Dopamine (59.20%) than Norepinephrin (57.30%) but it was statically not significant (P-value >0.05). Conclusion: Dopamine when compared with norepinephrine in this study was associated with more arrhythmias and with an increased rate of death in the subgroup of patients with cardiogenic shock. Although the rate of death did not differ significantly between the group of patients treated with dopamine and the group treated with norepinephrine." @default.
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- W2338194278 date "2016-04-01" @default.
- W2338194278 modified "2023-09-26" @default.
- W2338194278 title "OPEN LABEL STUDY OF INTENSIVE VASOPRESSORS THERAPY IN CRITICAL CARE- SURVIVAL BENEFITS vs SIDE EFFECTS" @default.
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- W2338194278 doi "https://doi.org/10.20530/ijta_32_1-4" @default.
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