FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338202423> ?p ?o ?g. }

• W2338202423 endingPage "1005" @default.
• W2338202423 startingPage "1000" @default.
• W2338202423 abstract "Chronic thromboembolic pulmonary hypertension (CTEPH) is an entity of PH that not only limits patients quality of life but also causes significant morbidity and mortality. The treatment of choice is pulmonary endarterectomy. However numerous patients do not qualify for pulmonary endarterectomy or present with residual vasculopathy post pulmonary endarterectomy and require specific vasodilator treatment. Currently, there is no available specific small animal model of CTEPH that could serve as tool to identify targetable molecular pathways and to test new treatment options. Thus, we generated and standardized a rat model that not only resembles functional and histological features of CTEPH but also emulates thrombi fibrosis. The pulmonary embolism protocol consisted of 3 sequential tail vein injections of fibrinogen/collagen-covered polystyrene microspheres combined with thrombin and administered to 10-week-old male Wistar rats. After the third embolism, rats developed characteristic features of CTEPH including elevated right ventricular systolic pressure, right ventricular cardiomyocyte hypertrophy, pulmonary artery remodeling, increased serum brain natriuretic peptide levels, thrombi fibrosis, and formation of pulmonary cellular-fibrotic lesions. The current animal model seems suitable for detailed study of CTEPH pathophysiology and permits preclinical testing of new pharmacological therapies against CTEPH." @default.
• W2338202423 created "2016-06-24" @default.
• W2338202423 creator A5018856613 @default.
• W2338202423 creator A5028639961 @default.
• W2338202423 creator A5037308970 @default.
• W2338202423 creator A5045268154 @default.
• W2338202423 creator A5064786839 @default.
• W2338202423 creator A5067633141 @default.
• W2338202423 creator A5071474093 @default.
• W2338202423 creator A5085083689 @default.
• W2338202423 date "2016-05-01" @default.
• W2338202423 modified "2023-09-24" @default.
• W2338202423 title "Development and Characterization of an Inducible Rat Model of Chronic Thromboembolic Pulmonary Hypertension" @default.
• W2338202423 cites W10297047 @default.
• W2338202423 cites W1975307252 @default.
• W2338202423 cites W1990877518 @default.
• W2338202423 cites W1993497485 @default.
• W2338202423 cites W1994536035 @default.
• W2338202423 cites W1997023449 @default.
• W2338202423 cites W2015742283 @default.
• W2338202423 cites W2019011121 @default.
• W2338202423 cites W2026599765 @default.
• W2338202423 cites W2029366364 @default.
• W2338202423 cites W2051486634 @default.
• W2338202423 cites W2053086946 @default.
• W2338202423 cites W2065552516 @default.
• W2338202423 cites W2090094198 @default.
• W2338202423 cites W2102024933 @default.
• W2338202423 cites W2102997357 @default.
• W2338202423 cites W2103457670 @default.
• W2338202423 cites W2107640422 @default.
• W2338202423 cites W2112385886 @default.
• W2338202423 cites W2113319085 @default.
• W2338202423 cites W2124392720 @default.
• W2338202423 cites W2128435880 @default.
• W2338202423 cites W2133936093 @default.
• W2338202423 cites W2159024307 @default.
• W2338202423 cites W3202340696 @default.
• W2338202423 cites W37743275 @default.
• W2338202423 doi "https://doi.org/10.1161/hypertensionaha.116.07247" @default.
• W2338202423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27045032" @default.
• W2338202423 hasPublicationYear "2016" @default.
• W2338202423 type Work @default.
• W2338202423 sameAs 2338202423 @default.
• W2338202423 citedByCount "14" @default.
• W2338202423 countsByYear W23382024232016 @default.
• W2338202423 countsByYear W23382024232017 @default.
• W2338202423 countsByYear W23382024232019 @default.
• W2338202423 countsByYear W23382024232020 @default.
• W2338202423 countsByYear W23382024232021 @default.
• W2338202423 countsByYear W23382024232022 @default.
• W2338202423 countsByYear W23382024232023 @default.
• W2338202423 crossrefType "journal-article" @default.
• W2338202423 hasAuthorship W2338202423A5018856613 @default.
• W2338202423 hasAuthorship W2338202423A5028639961 @default.
• W2338202423 hasAuthorship W2338202423A5037308970 @default.
• W2338202423 hasAuthorship W2338202423A5045268154 @default.
• W2338202423 hasAuthorship W2338202423A5064786839 @default.
• W2338202423 hasAuthorship W2338202423A5067633141 @default.
• W2338202423 hasAuthorship W2338202423A5071474093 @default.
• W2338202423 hasAuthorship W2338202423A5085083689 @default.
• W2338202423 hasBestOaLocation W23382024231 @default.
• W2338202423 hasConcept C126322002 @default.
• W2338202423 hasConcept C142724271 @default.
• W2338202423 hasConcept C164705383 @default.
• W2338202423 hasConcept C2775846464 @default.
• W2338202423 hasConcept C2776265017 @default.
• W2338202423 hasConcept C2777428986 @default.
• W2338202423 hasConcept C2778198053 @default.
• W2338202423 hasConcept C2779376020 @default.
• W2338202423 hasConcept C2780559512 @default.
• W2338202423 hasConcept C2780930700 @default.
• W2338202423 hasConcept C2780940725 @default.
• W2338202423 hasConcept C71924100 @default.
• W2338202423 hasConceptScore W2338202423C126322002 @default.
• W2338202423 hasConceptScore W2338202423C142724271 @default.
• W2338202423 hasConceptScore W2338202423C164705383 @default.
• W2338202423 hasConceptScore W2338202423C2775846464 @default.
• W2338202423 hasConceptScore W2338202423C2776265017 @default.
• W2338202423 hasConceptScore W2338202423C2777428986 @default.
• W2338202423 hasConceptScore W2338202423C2778198053 @default.
• W2338202423 hasConceptScore W2338202423C2779376020 @default.
• W2338202423 hasConceptScore W2338202423C2780559512 @default.
• W2338202423 hasConceptScore W2338202423C2780930700 @default.
• W2338202423 hasConceptScore W2338202423C2780940725 @default.
• W2338202423 hasConceptScore W2338202423C71924100 @default.
• W2338202423 hasIssue "5" @default.
• W2338202423 hasLocation W23382024231 @default.
• W2338202423 hasLocation W23382024232 @default.
• W2338202423 hasOpenAccess W2338202423 @default.
• W2338202423 hasPrimaryLocation W23382024231 @default.
• W2338202423 hasRelatedWork W2002597548 @default.
• W2338202423 hasRelatedWork W2033672119 @default.
• W2338202423 hasRelatedWork W2266382802 @default.
• W2338202423 hasRelatedWork W2333145688 @default.
• W2338202423 hasRelatedWork W2800275622 @default.
• W2338202423 hasRelatedWork W2900633055 @default.
• W2338202423 hasRelatedWork W3042980799 @default.

• next