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• W2338220650 abstract "Perimenopause, rather than a time of declining estrogen, is characterized by three major hormonal changes that may begin in regularly menstruating women in their mid-thirties: erratically higher estradiol levels, decreased progesterone levels (in normally ovulatory, short luteal phase or anovulatory cycles), and disturbed ovarian-pituitary-hypothalamic feedback relationships. Recent data show that approximately a third of all perimenopausal cycles have a major surge in estradiol occurring de novo during the luteal phase. This phenomenon, named luteal out of phase (LOOP) event, may explain a large proportion of symptoms and signs for symptomatic perimenopausal women. Large urinary hormone data-sets from women studied yearly over a number of years in the Study of Women Across the Nation (SWAN) and in the Tremin data will eventually provide a more clear prospective understanding of within-woman hormonal changes. Predicting menopause proximity with FSH or Inhibin B levels is documented to be ineffective. Anti-Mullerian hormone levels may prove predictive. Finally, there is an urgent need to change perimenopause understandings, language and therapies used for midlife women's symptoms to reflect these hormonal changes." @default.
• W2338220650 created "2016-06-24" @default.
• W2338220650 creator A5027489501 @default.
• W2338220650 creator A5031836057 @default.
• W2338220650 date "2011-01-01" @default.
• W2338220650 modified "2023-09-23" @default.
• W2338220650 title "The endocrinology of perimenopause need for a paradigm shift" @default.
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• W2338220650 doi "https://doi.org/10.2741/s166" @default.
• W2338220650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21196391" @default.
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