FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338289743> ?p ?o ?g. }

• W2338289743 endingPage "e0139981" @default.
• W2338289743 startingPage "e0139981" @default.
• W2338289743 abstract "Introduction The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR-145 correlated with nadir CD4+ T cell count. Discussion No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection." @default.
• W2338289743 created "2016-06-24" @default.
• W2338289743 creator A5000134470 @default.
• W2338289743 creator A5000138586 @default.
• W2338289743 creator A5000226472 @default.
• W2338289743 creator A5000226542 @default.
• W2338289743 creator A5000296671 @default.
• W2338289743 creator A5000368717 @default.
• W2338289743 creator A5000412661 @default.
• W2338289743 creator A5000418614 @default.
• W2338289743 creator A5000552799 @default.
• W2338289743 creator A5000764626 @default.
• W2338289743 creator A5000898404 @default.
• W2338289743 creator A5000969643 @default.
• W2338289743 creator A5000971999 @default.
• W2338289743 creator A5000992456 @default.
• W2338289743 creator A5001026149 @default.
• W2338289743 creator A5001045724 @default.
• W2338289743 creator A5001132562 @default.
• W2338289743 creator A5001211857 @default.
• W2338289743 creator A5001241744 @default.
• W2338289743 creator A5001303096 @default.
• W2338289743 creator A5001331694 @default.
• W2338289743 creator A5001339586 @default.
• W2338289743 creator A5001375239 @default.
• W2338289743 creator A5001410812 @default.
• W2338289743 creator A5001487991 @default.
• W2338289743 creator A5001515596 @default.
• W2338289743 creator A5001627023 @default.
• W2338289743 creator A5001628235 @default.
• W2338289743 creator A5001753109 @default.
• W2338289743 creator A5001780394 @default.
• W2338289743 creator A5001806489 @default.
• W2338289743 creator A5001859689 @default.
• W2338289743 creator A5001957023 @default.
• W2338289743 creator A5002095009 @default.
• W2338289743 creator A5002098185 @default.
• W2338289743 creator A5002103695 @default.
• W2338289743 creator A5002235416 @default.
• W2338289743 creator A5002335985 @default.
• W2338289743 creator A5002341488 @default.
• W2338289743 creator A5002398162 @default.
• W2338289743 creator A5002402949 @default.
• W2338289743 creator A5002501603 @default.
• W2338289743 creator A5002605046 @default.
• W2338289743 creator A5002655160 @default.
• W2338289743 creator A5002721139 @default.
• W2338289743 creator A5002806903 @default.
• W2338289743 creator A5002847672 @default.
• W2338289743 creator A5002944906 @default.
• W2338289743 creator A5002975139 @default.
• W2338289743 creator A5003017347 @default.
• W2338289743 creator A5003031235 @default.
• W2338289743 creator A5003042131 @default.
• W2338289743 creator A5003135751 @default.
• W2338289743 creator A5003266513 @default.
• W2338289743 creator A5003323389 @default.
• W2338289743 creator A5003425808 @default.
• W2338289743 creator A5003503698 @default.
• W2338289743 creator A5003807854 @default.
• W2338289743 creator A5003874003 @default.
• W2338289743 creator A5003962317 @default.
• W2338289743 creator A5003990288 @default.
• W2338289743 creator A5003996561 @default.
• W2338289743 creator A5004062566 @default.
• W2338289743 creator A5004079054 @default.
• W2338289743 creator A5004174170 @default.
• W2338289743 creator A5004217534 @default.
• W2338289743 creator A5004426130 @default.
• W2338289743 creator A5004476613 @default.
• W2338289743 creator A5004504761 @default.
• W2338289743 creator A5004618983 @default.
• W2338289743 creator A5004650909 @default.
• W2338289743 creator A5004702901 @default.
• W2338289743 creator A5004723951 @default.
• W2338289743 creator A5004759436 @default.
• W2338289743 creator A5004912241 @default.
• W2338289743 creator A5004979265 @default.
• W2338289743 creator A5004991596 @default.
• W2338289743 creator A5005199364 @default.
• W2338289743 creator A5005244410 @default.
• W2338289743 creator A5005252476 @default.
• W2338289743 creator A5005349484 @default.
• W2338289743 creator A5005368354 @default.
• W2338289743 creator A5005369235 @default.
• W2338289743 creator A5005733938 @default.
• W2338289743 creator A5005819888 @default.
• W2338289743 creator A5005837829 @default.
• W2338289743 creator A5005841543 @default.
• W2338289743 creator A5005862907 @default.
• W2338289743 creator A5005873062 @default.
• W2338289743 creator A5005954445 @default.
• W2338289743 creator A5006323095 @default.
• W2338289743 creator A5006365972 @default.
• W2338289743 creator A5006415647 @default.
• W2338289743 creator A5006503257 @default.
• W2338289743 creator A5006562143 @default.
• W2338289743 creator A5006623516 @default.

• next