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• W2338289905 abstract "Scope Expression of intercellular adhesion molecule‐1 (ICAM‐1) on vascular smooth muscle cells (VSMCs) plays an important role in the progression of atherosclerosis. We investigated the effects of bamboo stem extract (BSE) on motility and ICAM‐1 expression by using mouse MOVAS‐1 cells. Active constituents of BSE exhibiting an inhibitory activity on TNF‐α‐induced ICAM1 expression were identified using HPLC. Methods and results The effects of BSE on platelet‐derived growth factor (PDGF)‐BB‐induced migration, tumor necrosis factor alpha (TNF‐α)‐induced expression of ICAM‐1, and nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) activation were investigated. BSE inhibited migration of MOVAS‐1 cells and sprout formation by mouse aorta explants. Reverse transcription PCR analysis and promoter reporter assays revealed that BSE suppressed ICAM‐1 expression by inhibiting NF‐κB activity. In addition, BSE reduced adhesion between VSMCs and monocytes. Several oligosaccharides were identified in BSE. Among the oligosaccharides contained in BSE, maltotetraose and stachyose were potent inhibitors of TNF‐α‐induced ICAM‐1 expression. We confirmed that maltotetraose reduced PDGF‐induced sprout formation by mouse aorta explants and inhibited TNF‐α‐induced NF‐κB activation and ICAM‐1 expression in MOVAS‐1 cells. Conclusion The BSE constituent maltotetraose may be beneficial in the suppression of early atherosclerosis development and could be developed as a dietary supplement for cardiovascular health." @default.
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• W2338289905 date "2016-05-25" @default.
• W2338289905 modified "2023-10-14" @default.
• W2338289905 title "Inhibition of PDGF-induced migration and TNF-α-induced ICAM-1 expression by maltotetraose from bamboo stem extract (BSE) in mouse vascular smooth muscle cells" @default.
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• W2338289905 doi "https://doi.org/10.1002/mnfr.201500601" @default.
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