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- W2338343808 abstract "The establishment of a functional placenta is pivotal for normal fetal development and the maintenance of pregnancy. In the course of early placentation, trophoblast precursors differentiate into highly invasive trophoblast subtypes. These cells, referred to as extravillous trophoblasts (EVTs), penetrate the maternal uterus reaching as far as the inner third of the myometrium. One of the most fundamental functions of EVTs is the transformation of spiral arteries to establish the uteroplacental blood circulation assuring an adequate nutrient and gas supply to the developing fetus. To achieve this, specialized EVT subpopulations interact with maternal immune cells, provoke elastolysis in the arterial wall and replace the endothelial cells lining the spiral arteries to induce intraluminal vascular remodeling. These and other trophoblast-mediated processes are tightly controlled by paracrine signals from the maternal decidua and furthermore underlie an intrinsic cell-type specific program. Various severe pregnancy complications such as preeclampsia or intrauterine growth retardation are associated with abnormal EVT function, shallow invasion, and decreased blood flow to the placenta. Hence a better understanding of human trophoblast invasion seems mandatory to improve therapeutic intervention. This approach, however, requires a profound knowledge of the human placenta, its various trophoblast subtypes and in particular a better understanding of the regulatory network that controls the invasive phenotype of EVTs." @default.
- W2338343808 created "2016-06-24" @default.
- W2338343808 creator A5020628846 @default.
- W2338343808 creator A5061795013 @default.
- W2338343808 creator A5073970281 @default.
- W2338343808 date "2016-02-03" @default.
- W2338343808 modified "2023-10-17" @default.
- W2338343808 title "Function and control of human invasive trophoblast subtypes: Intrinsic vs. maternal control" @default.
- W2338343808 cites W109256707 @default.
- W2338343808 cites W126842556 @default.
- W2338343808 cites W1504432705 @default.
- W2338343808 cites W1506021195 @default.
- W2338343808 cites W1533471141 @default.
- W2338343808 cites W1601426514 @default.
- W2338343808 cites W1619770660 @default.
- W2338343808 cites W171819190 @default.
- W2338343808 cites W1918962518 @default.
- W2338343808 cites W1972823867 @default.
- W2338343808 cites W1975195151 @default.
- W2338343808 cites W1978675308 @default.
- W2338343808 cites W1983366064 @default.
- W2338343808 cites W1984953670 @default.
- W2338343808 cites W1984970610 @default.
- W2338343808 cites W1986371165 @default.
- W2338343808 cites W1989207860 @default.
- W2338343808 cites W1993274418 @default.
- W2338343808 cites W1996307378 @default.
- W2338343808 cites W1997529430 @default.
- W2338343808 cites W1997755063 @default.
- W2338343808 cites W2000520991 @default.
- W2338343808 cites W2002137646 @default.
- W2338343808 cites W2013435992 @default.
- W2338343808 cites W2017065802 @default.
- W2338343808 cites W2020621448 @default.
- W2338343808 cites W2021970761 @default.
- W2338343808 cites W2023447334 @default.
- W2338343808 cites W2027617631 @default.
- W2338343808 cites W2028178783 @default.
- W2338343808 cites W2028369131 @default.
- W2338343808 cites W2032861845 @default.
- W2338343808 cites W2042733876 @default.
- W2338343808 cites W2051299325 @default.
- W2338343808 cites W2051824079 @default.
- W2338343808 cites W2052472879 @default.
- W2338343808 cites W2064540829 @default.
- W2338343808 cites W2065545997 @default.
- W2338343808 cites W2071338376 @default.
- W2338343808 cites W2071927361 @default.
- W2338343808 cites W2072177711 @default.
- W2338343808 cites W2079853478 @default.
- W2338343808 cites W2081871156 @default.
- W2338343808 cites W2083444590 @default.
- W2338343808 cites W2089611230 @default.
- W2338343808 cites W2090583597 @default.
- W2338343808 cites W2091860804 @default.
- W2338343808 cites W2093060517 @default.
- W2338343808 cites W2093227175 @default.
- W2338343808 cites W2095070616 @default.
- W2338343808 cites W2096085246 @default.
- W2338343808 cites W2102277066 @default.
- W2338343808 cites W2105582131 @default.
- W2338343808 cites W2108942738 @default.
- W2338343808 cites W2116319421 @default.
- W2338343808 cites W2116669943 @default.
- W2338343808 cites W2116917152 @default.
- W2338343808 cites W2119084006 @default.
- W2338343808 cites W2120468749 @default.
- W2338343808 cites W2121997180 @default.
- W2338343808 cites W2123070897 @default.
- W2338343808 cites W2124652493 @default.
- W2338343808 cites W2130851276 @default.
- W2338343808 cites W2132470450 @default.
- W2338343808 cites W2133618586 @default.
- W2338343808 cites W2136960342 @default.
- W2338343808 cites W2139614257 @default.
- W2338343808 cites W2141003443 @default.
- W2338343808 cites W2143498816 @default.
- W2338343808 cites W2145809469 @default.
- W2338343808 cites W2148918439 @default.
- W2338343808 cites W2150967160 @default.
- W2338343808 cites W2151162913 @default.
- W2338343808 cites W2155899146 @default.
- W2338343808 cites W2157128532 @default.
- W2338343808 cites W2163307816 @default.
- W2338343808 cites W2165010587 @default.
- W2338343808 cites W2166223726 @default.
- W2338343808 cites W2171391855 @default.
- W2338343808 cites W2416686379 @default.
- W2338343808 doi "https://doi.org/10.1080/19336918.2015.1089376" @default.
- W2338343808 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4853032" @default.
- W2338343808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26418186" @default.
- W2338343808 hasPublicationYear "2016" @default.
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