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- W2338349804 abstract "Both a rodent and a nonrodent species are required for evaluation in nonclinical safety studies conducted to support human clinical trials. Historically, dogs and nonhuman primates have been the nonrodent species of choice. Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety as an alternate nonrodent species. The pig is an appropriate option for these toxicology studies based on metabolic pathways utilized in xenobiotic biotransformation. Both similarities and differences exist in phase I and phase II biotransformation pathways between humans and pigs. There are numerous breeds of pigs, yet only a few of these breeds are characterized with regard to both xenobiotic-metabolizing enzymes and background pathology findings. Some specific differences in these enzymes based on breed and sex are known. Although swine have been used extensively in biomedical research, there is also a paucity of information in the current literature detailing the incidence of background lesions and differences between commonly used breeds. Here, the xenobiotic-metabolizing enzymes are compared between humans and pigs, and minipig background pathology changes are reviewed with emphasis on breed differences." @default.
- W2338349804 created "2016-06-24" @default.
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- W2338349804 date "2016-04-04" @default.
- W2338349804 modified "2023-10-18" @default.
- W2338349804 title "Pigs in Toxicology" @default.
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- W2338349804 cites W1884477691 @default.
- W2338349804 cites W1963519745 @default.
- W2338349804 cites W1963688752 @default.
- W2338349804 cites W1967026367 @default.
- W2338349804 cites W1969875307 @default.
- W2338349804 cites W1972086924 @default.
- W2338349804 cites W1977173693 @default.
- W2338349804 cites W1982111901 @default.
- W2338349804 cites W1983392438 @default.
- W2338349804 cites W1987245317 @default.
- W2338349804 cites W1993401850 @default.
- W2338349804 cites W2005328285 @default.
- W2338349804 cites W2007025633 @default.
- W2338349804 cites W2007052092 @default.
- W2338349804 cites W2008615088 @default.
- W2338349804 cites W2009142459 @default.
- W2338349804 cites W2014797188 @default.
- W2338349804 cites W2015720516 @default.
- W2338349804 cites W2016990891 @default.
- W2338349804 cites W2017176118 @default.
- W2338349804 cites W2017745597 @default.
- W2338349804 cites W2023003226 @default.
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- W2338349804 cites W2039004255 @default.
- W2338349804 cites W2040222743 @default.
- W2338349804 cites W2041146258 @default.
- W2338349804 cites W2042057388 @default.
- W2338349804 cites W2047287660 @default.
- W2338349804 cites W2049480378 @default.
- W2338349804 cites W2049964526 @default.
- W2338349804 cites W2051863978 @default.
- W2338349804 cites W2051911399 @default.
- W2338349804 cites W2056755823 @default.
- W2338349804 cites W2060918976 @default.
- W2338349804 cites W2066570208 @default.
- W2338349804 cites W2071693622 @default.
- W2338349804 cites W2075183347 @default.
- W2338349804 cites W2085541402 @default.
- W2338349804 cites W2086150088 @default.
- W2338349804 cites W2086953975 @default.
- W2338349804 cites W2087709358 @default.
- W2338349804 cites W2089007738 @default.
- W2338349804 cites W2097100227 @default.
- W2338349804 cites W2098547087 @default.
- W2338349804 cites W2107926590 @default.
- W2338349804 cites W2114823689 @default.
- W2338349804 cites W2115143029 @default.
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- W2338349804 cites W2135140303 @default.
- W2338349804 cites W2136661246 @default.
- W2338349804 cites W2136899763 @default.
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- W2338349804 cites W2164225375 @default.
- W2338349804 cites W2167227549 @default.
- W2338349804 cites W2169573748 @default.
- W2338349804 cites W2170139938 @default.
- W2338349804 cites W2170581254 @default.
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- W2338349804 doi "https://doi.org/10.1177/0192623316639389" @default.
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