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• W2338397989 abstract "Thyrotropin-releasing hormone (TRH) in the paraventricular nucleus (PVN) of the hypothalamus is regulated by thyroid hormone (TH). cAMP response element binding protein (CREB) has also been postulated to regulate TRH expression but its interaction with TH signaling in vivo is not known. To evaluate the role of CREB in TRH regulation in vivo, we deleted CREB from PVN neurons to generate the CREB1ΔSIM1 mouse. As previously shown, loss of CREB was compensated for by an up-regulation of CREM in euthyroid CREB1ΔSIM1 mice but TSH, T4 and T3 levels were normal, even though TRH mRNA levels were elevated. Interestingly, TRH mRNA expression was also increased in the PVN of CREB1ΔSIM1 mice in the hypothyroid state but became normal when made hyperthyroid. Importantly, CREM levels were similar in CREB1ΔSIM1 mice regardless of thyroid status, demonstrating that the regulation of TRH by T3 in vivo likely occurs independently of the CREB/CREM family." @default.
• W2338397989 created "2016-06-24" @default.
• W2338397989 creator A5051733355 @default.
• W2338397989 creator A5087352271 @default.
• W2338397989 date "1975-09-01" @default.
• W2338397989 modified "2023-10-17" @default.
• W2338397989 title "The Hypothalamic-Pituitary-Thyroid Axis" @default.
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• W2338397989 doi "https://doi.org/10.1016/s0025-7125(16)31955-1" @default.
• W2338397989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/808671" @default.
• W2338397989 hasPublicationYear "1975" @default.
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