Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338403880> ?p ?o ?g. }
- W2338403880 endingPage "430" @default.
- W2338403880 startingPage "420" @default.
- W2338403880 abstract "Clinical management of breast cancer is increasingly personalized and based on molecular profiling. Often, primary tumors are used as proxies for systemic disease at the time of recurrence. However, recent studies have revealed substantial discordances between primary tumors and metastases, both with respect to traditional clinical treatment targets and on the genomic and transcriptomic level. With the increasing use of molecularly targeted therapy, discordance of actionable molecular targets between primary tumors and recurrences can result in nonoptimal treatment or unnecessary side effects. The purpose of this review is to illuminate the extent of cancer genome evolution through disease progression and the degree of molecular concordance between primary breast cancers and matched metastases. We present an overview of the most prominent studies investigating the expression of endocrine receptors, transcriptomics, and genome aberrations in primary tumors and metastases. In conclusion, biopsy of metastatic lesions at recurrence of breast cancer is encouraged to provide optimal treatment of the disease. Furthermore, molecular profiling of metastatic tissue provides invaluable mechanistic insight into the biology underlying metastatic progression and has the potential to identify novel, potentially druggable, drivers of progression." @default.
- W2338403880 created "2016-06-24" @default.
- W2338403880 creator A5017827589 @default.
- W2338403880 creator A5021109428 @default.
- W2338403880 creator A5075169782 @default.
- W2338403880 creator A5077825277 @default.
- W2338403880 date "2016-04-18" @default.
- W2338403880 modified "2023-09-27" @default.
- W2338403880 title "Molecular Concordance Between Primary Breast Cancer and Matched Metastases" @default.
- W2338403880 cites W1807491301 @default.
- W2338403880 cites W1964231749 @default.
- W2338403880 cites W1964538769 @default.
- W2338403880 cites W1967497779 @default.
- W2338403880 cites W1968328642 @default.
- W2338403880 cites W1974685860 @default.
- W2338403880 cites W1979946545 @default.
- W2338403880 cites W1985029299 @default.
- W2338403880 cites W2000127593 @default.
- W2338403880 cites W2004834404 @default.
- W2338403880 cites W2006492098 @default.
- W2338403880 cites W2013282239 @default.
- W2338403880 cites W2014768527 @default.
- W2338403880 cites W2016590830 @default.
- W2338403880 cites W2023694015 @default.
- W2338403880 cites W2023915585 @default.
- W2338403880 cites W2034849223 @default.
- W2338403880 cites W2035503570 @default.
- W2338403880 cites W2035522845 @default.
- W2338403880 cites W2037966798 @default.
- W2338403880 cites W2057794558 @default.
- W2338403880 cites W2058865073 @default.
- W2338403880 cites W2073155340 @default.
- W2338403880 cites W2073427945 @default.
- W2338403880 cites W2077966621 @default.
- W2338403880 cites W2084306763 @default.
- W2338403880 cites W2090011230 @default.
- W2338403880 cites W2091430335 @default.
- W2338403880 cites W2093829133 @default.
- W2338403880 cites W2096817916 @default.
- W2338403880 cites W2097665397 @default.
- W2338403880 cites W2099117820 @default.
- W2338403880 cites W2101880436 @default.
- W2338403880 cites W2103767336 @default.
- W2338403880 cites W2103894337 @default.
- W2338403880 cites W2116834581 @default.
- W2338403880 cites W2119048498 @default.
- W2338403880 cites W2119065193 @default.
- W2338403880 cites W2119569174 @default.
- W2338403880 cites W2127609858 @default.
- W2338403880 cites W2130828084 @default.
- W2338403880 cites W2132388337 @default.
- W2338403880 cites W2135890715 @default.
- W2338403880 cites W2140575188 @default.
- W2338403880 cites W2143764959 @default.
- W2338403880 cites W2147354890 @default.
- W2338403880 cites W2152628477 @default.
- W2338403880 cites W2157434805 @default.
- W2338403880 cites W2158111334 @default.
- W2338403880 cites W2168424827 @default.
- W2338403880 cites W2170061824 @default.
- W2338403880 cites W2170872221 @default.
- W2338403880 cites W2314556209 @default.
- W2338403880 cites W2917837889 @default.
- W2338403880 cites W4230263812 @default.
- W2338403880 cites W4234081105 @default.
- W2338403880 doi "https://doi.org/10.1111/tbj.12596" @default.
- W2338403880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27089067" @default.
- W2338403880 hasPublicationYear "2016" @default.
- W2338403880 type Work @default.
- W2338403880 sameAs 2338403880 @default.
- W2338403880 citedByCount "38" @default.
- W2338403880 countsByYear W23384038802016 @default.
- W2338403880 countsByYear W23384038802017 @default.
- W2338403880 countsByYear W23384038802018 @default.
- W2338403880 countsByYear W23384038802019 @default.
- W2338403880 countsByYear W23384038802020 @default.
- W2338403880 countsByYear W23384038802021 @default.
- W2338403880 countsByYear W23384038802022 @default.
- W2338403880 countsByYear W23384038802023 @default.
- W2338403880 crossrefType "journal-article" @default.
- W2338403880 hasAuthorship W2338403880A5017827589 @default.
- W2338403880 hasAuthorship W2338403880A5021109428 @default.
- W2338403880 hasAuthorship W2338403880A5075169782 @default.
- W2338403880 hasAuthorship W2338403880A5077825277 @default.
- W2338403880 hasBestOaLocation W23384038801 @default.
- W2338403880 hasConcept C104317684 @default.
- W2338403880 hasConcept C10679952 @default.
- W2338403880 hasConcept C121608353 @default.
- W2338403880 hasConcept C126322002 @default.
- W2338403880 hasConcept C143998085 @default.
- W2338403880 hasConcept C150194340 @default.
- W2338403880 hasConcept C160798450 @default.
- W2338403880 hasConcept C18431079 @default.
- W2338403880 hasConcept C2775930923 @default.
- W2338403880 hasConcept C2779013556 @default.
- W2338403880 hasConcept C2779134260 @default.
- W2338403880 hasConcept C2780283643 @default.
- W2338403880 hasConcept C530470458 @default.