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• W2338433455 startingPage "635" @default.
• W2338433455 abstract "Dextran sulfate sodium (DS) was allowed to interact ionically with ropinirole hydrochloride (ROPI HCl, an anti-Parkinsonian agent) to synthesize self-assembled ROPI-DS nanoplex. The preliminary objective behind ROPI-DS complexation was to enhance the partitioning of ROPI HCl and thereby its encapsulation into nanocarriers and to improve the nasal membrane permeability. Molecular interactions were computed using in silico molecular modeling. Nanoplex were characterized for physicochemical and partitioning behavior. Optimized ROPI-DS nanoplex was further characterized by spectroscopic and thermal analysis, diffraction studies, morphological and histopathological analysis. In summary, ROPI-DS nanoplex represents a promising nanocarrier material for intranasal administration." @default.
• W2338433455 created "2016-06-24" @default.
• W2338433455 creator A5054978082 @default.
• W2338433455 creator A5071581118 @default.
• W2338433455 date "2016-04-11" @default.
• W2338433455 modified "2023-09-26" @default.
• W2338433455 title "Ropinirole-dextran sulfate nanoplex for nasal administration against Parkinson’s disease: <i>in silico</i> molecular modeling and <i>in vitro</i>–<i>ex vivo</i> evaluation" @default.
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• W2338433455 doi "https://doi.org/10.3109/21691401.2016.1167703" @default.
• W2338433455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27068140" @default.
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