FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338454059> ?p ?o ?g. }

• W2338454059 endingPage "4459" @default.
• W2338454059 startingPage "4450" @default.
• W2338454059 abstract "Loop–loop (also known as kissing) interactions between RNA hairpins are involved in several mechanisms in both prokaryotes and eukaryotes such as the regulation of the plasmid copy number or the dimerization of retroviral genomes. The stability of kissing complexes relies on loop parameters (base composition, sequence and size) and base combination at the loop–loop helix - stem junctions. In order to identify kissing partners that could be used as regulatory elements or building blocks of RNA scaffolds, we analysed a pool of 5.2 × 106 RNA hairpins with randomized loops. We identified more than 50 pairs of kissing RNA hairpins. Two kissing motifs, 5′CCNY and 5′RYRY, generate highly stable complexes with KDs in the low nanomolar range. Such motifs were introduced in the apical loop of hairpin aptamers that switch between unfolded and folded state upon binding to their cognate target molecule, hence their name aptaswitch. The aptaswitch–ligand complex is specifically recognized by a second RNA hairpin named aptakiss through loop–loop interaction. Taking advantage of our kissing motif repertoire we engineered aptaswitch–aptakiss modules for purine derivatives, namely adenosine, GTP and theophylline and demonstrated that these molecules can be specifically and simultaneously detected by surface plasmon resonance or by fluorescence anisotropy." @default.
• W2338454059 created "2016-06-24" @default.
• W2338454059 creator A5005643368 @default.
• W2338454059 creator A5040980725 @default.
• W2338454059 creator A5051450660 @default.
• W2338454059 creator A5051513414 @default.
• W2338454059 creator A5062607453 @default.
• W2338454059 creator A5087149618 @default.
• W2338454059 creator A5087312850 @default.
• W2338454059 date "2016-04-11" @default.
• W2338454059 modified "2023-10-05" @default.
• W2338454059 title "A combinatorial approach to the repertoire of RNA kissing motifs; towards multiplex detection by switching hairpin aptamers" @default.
• W2338454059 cites W1568237548 @default.
• W2338454059 cites W1579537489 @default.
• W2338454059 cites W1819107170 @default.
• W2338454059 cites W1873825682 @default.
• W2338454059 cites W1965827686 @default.
• W2338454059 cites W1968372195 @default.
• W2338454059 cites W1970478438 @default.
• W2338454059 cites W1973901059 @default.
• W2338454059 cites W1977228715 @default.
• W2338454059 cites W1993411667 @default.
• W2338454059 cites W1997511581 @default.
• W2338454059 cites W1997884783 @default.
• W2338454059 cites W1998352029 @default.
• W2338454059 cites W2000282677 @default.
• W2338454059 cites W2001266427 @default.
• W2338454059 cites W2015535589 @default.
• W2338454059 cites W2019309102 @default.
• W2338454059 cites W2020026818 @default.
• W2338454059 cites W2020790990 @default.
• W2338454059 cites W2022012719 @default.
• W2338454059 cites W2022681517 @default.
• W2338454059 cites W2026517651 @default.
• W2338454059 cites W2029735376 @default.
• W2338454059 cites W2033567222 @default.
• W2338454059 cites W2034958387 @default.
• W2338454059 cites W2038652232 @default.
• W2338454059 cites W2051116783 @default.
• W2338454059 cites W2051699902 @default.
• W2338454059 cites W2054107485 @default.
• W2338454059 cites W2061530854 @default.
• W2338454059 cites W2065356339 @default.
• W2338454059 cites W2069105811 @default.
• W2338454059 cites W2070393893 @default.
• W2338454059 cites W2072013830 @default.
• W2338454059 cites W2077734499 @default.
• W2338454059 cites W2077845874 @default.
• W2338454059 cites W2084373725 @default.
• W2338454059 cites W2088784401 @default.
• W2338454059 cites W2090131332 @default.
• W2338454059 cites W2092867893 @default.
• W2338454059 cites W2099892842 @default.
• W2338454059 cites W2100808809 @default.
• W2338454059 cites W2101326349 @default.
• W2338454059 cites W2104585673 @default.
• W2338454059 cites W2112192177 @default.
• W2338454059 cites W2117223714 @default.
• W2338454059 cites W2125430914 @default.
• W2338454059 cites W2128899933 @default.
• W2338454059 cites W2150391637 @default.
• W2338454059 cites W2151309141 @default.
• W2338454059 cites W2152891632 @default.
• W2338454059 cites W2154071879 @default.
• W2338454059 cites W2158888617 @default.
• W2338454059 cites W2159834224 @default.
• W2338454059 cites W2162215330 @default.
• W2338454059 cites W2163132518 @default.
• W2338454059 cites W2317296341 @default.
• W2338454059 cites W2318081180 @default.
• W2338454059 cites W310615253 @default.
• W2338454059 cites W4241821763 @default.
• W2338454059 cites W586903975 @default.
• W2338454059 doi "https://doi.org/10.1093/nar/gkw206" @default.
• W2338454059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4872101" @default.
• W2338454059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27067541" @default.
• W2338454059 hasPublicationYear "2016" @default.
• W2338454059 type Work @default.
• W2338454059 sameAs 2338454059 @default.
• W2338454059 citedByCount "26" @default.
• W2338454059 countsByYear W23384540592017 @default.
• W2338454059 countsByYear W23384540592018 @default.
• W2338454059 countsByYear W23384540592019 @default.
• W2338454059 countsByYear W23384540592020 @default.
• W2338454059 countsByYear W23384540592021 @default.
• W2338454059 countsByYear W23384540592022 @default.
• W2338454059 countsByYear W23384540592023 @default.
• W2338454059 crossrefType "journal-article" @default.
• W2338454059 hasAuthorship W2338454059A5005643368 @default.
• W2338454059 hasAuthorship W2338454059A5040980725 @default.
• W2338454059 hasAuthorship W2338454059A5051450660 @default.
• W2338454059 hasAuthorship W2338454059A5051513414 @default.
• W2338454059 hasAuthorship W2338454059A5062607453 @default.
• W2338454059 hasAuthorship W2338454059A5087149618 @default.
• W2338454059 hasAuthorship W2338454059A5087312850 @default.
• W2338454059 hasBestOaLocation W23384540591 @default.
• W2338454059 hasConcept C104317684 @default.
• W2338454059 hasConcept C12554922 @default.

• next