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- W2338502012 abstract "Gene expression patterns in normal and cancer cells are regulated by the coordinated activity of epigenetic writers, erasers, and readers. Silencing of tumor suppressor genes and activation of oncogenes in cancer cells are the results of alterations in DNA methylation, histone modifications, and chromatin remodelers. Epigenetic therapy, using single agents designed to target specific epigenetic alterations in cancer, has demonstrated some activity which has led to several drug approvals in recent years. Although effective, epigenetic drugs as monotherapy produce responses in a minority of patients and complete remissions are generally of short duration. However, simultaneously targeting multiple epigenetic mechanisms can lead to synergistic responses by enhancing gene expression reprogramming, cancer cell differentiation, and ultimately cancer cell death. Preclinical studies and some clinical trials have demonstrated the efficacy of combined epigenetic therapies. New epigenetic combinations are currently tested in several clinical trials for cancer chemotherapy." @default.
- W2338502012 created "2016-06-24" @default.
- W2338502012 creator A5038157289 @default.
- W2338502012 date "2016-01-01" @default.
- W2338502012 modified "2023-10-03" @default.
- W2338502012 title "Efficacy of Combined Epigenetic Therapies" @default.
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