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• W2338567511 abstract "adenomas. To characterize the cell type of these tumors, we analyzed pituitary hormone gene expression in clinically nonfunctioning pituitary adenomas using specific oligonucleotide probes for the messenger (m)RNAs encoding growth hormone, prolactin, ACIH, and the glycoprotein hormone subunits, a, luteinizing hormone (LH)/3, follicle-stimulating hormone (FSH)/3, and thyroid-stimulating hormone (TSH),8. Expression ofone or more ofthe anterior pituitary hormone genes was found in 2A/4 (86%) of the patients with clinically classified nonfunctioning adenomas. Expression of one or more of the glycoprotein hormone genes (a, LHfl, FSH,6, TSHft) was identified most commonly (79%) with expression of multiple /3-subunit genes in many cases. Expression of a-subunit mRNA was found in each of the adenomas from patients expressing one of the /3-subunit mRNAs and in three patients with no detectable /3-subunit mRNA. Although FSHft and LH,6 mRNAs were found with similar frequencies in nonfunctioning adenomas, expression of FSH/3 mRNA was generally much more abundant. TSHft mRNA was detected in only one adenoma. The levels of glycoprotein hormone subunit mRNAs were variable in different adenomas, but the lengths of the mRNAs and transcriptional start sites for the a- and /3-subunit genes were the same in the pituitary adenomas and in normal pituitary. Growth hormone and prolactin gene expression were not observed in the nonfunctioning adenomas, but ACTH mRNA was found in a single case. Immunohistochemistry of the adenomas confirmed production of one or more pituitary hormones in 3/14 (93%) nonfunctioning tumors, with a distribution of hormone production similar to that of the hormone mRNAs. These data indicate that pituitary adenomas originating from cells producing glycoprotein hormones are common, but are difficult to recognize clinically because of the absence of characteristic endocrine syndromes and defective hormone" @default.
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• W2338567511 date "1987-01-01" @default.
• W2338567511 modified "2023-09-24" @default.
• W2338567511 title "in Clinically Nonfunctioning Pituitary Adenomas" @default.
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