Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338571857> ?p ?o ?g. }
- W2338571857 endingPage "10773" @default.
- W2338571857 startingPage "10764" @default.
- W2338571857 abstract "When injected in a biological milieu, a nanomaterial rapidly adsorbs biomolecules forming a biomolecular corona. The biomolecular corona changes the interfacial composition of a nanomaterial giving it a biological identity that determines the physiological response. Characterization of the biomolecular structure and composition has received increasing attention mostly due to its detrimental impact on the nanomaterial's metabolism in vivo. It is generally accepted that an opsonin-enriched biomolecular corona promotes immune system recognition and rapid clearance from circulation. Here we applied dynamic light scattering and nanoliquid chromatography tandem mass spectrometry to thoroughly characterize the biomolecular corona formed around lipid and silica nanoparticles (NPs). Incubation with human plasma resulted in the formation of NP-biomolecular coronas enriched with immunoglobulins, complement factors, and coagulation proteins that bind to surface receptors on immune cells and elicit phagocytosis. Conversely, we found that protein-coated NPs were protected from uptake by macrophage RAW 264.7 cells. This implies that the biomolecular corona formation provides a stealth effect on macrophage recognition. Our results suggest that correct prediction of the NP's fate in vivo will require more than just the knowledge of the biomolecular corona composition. Validation of efficient methods for mapping protein binding sites on the biomolecular corona of NPs is an urgent task for future research." @default.
- W2338571857 created "2016-06-24" @default.
- W2338571857 creator A5013516500 @default.
- W2338571857 creator A5040610833 @default.
- W2338571857 creator A5048033242 @default.
- W2338571857 creator A5051147546 @default.
- W2338571857 creator A5051824751 @default.
- W2338571857 creator A5068820590 @default.
- W2338571857 creator A5075387837 @default.
- W2338571857 creator A5082409429 @default.
- W2338571857 date "2015-09-25" @default.
- W2338571857 modified "2023-09-30" @default.
- W2338571857 title "Stealth Effect of Biomolecular Corona on Nanoparticle Uptake by Immune Cells" @default.
- W2338571857 cites W1510451667 @default.
- W2338571857 cites W1963565300 @default.
- W2338571857 cites W1966138161 @default.
- W2338571857 cites W1973831032 @default.
- W2338571857 cites W1978542424 @default.
- W2338571857 cites W1989329597 @default.
- W2338571857 cites W1989451021 @default.
- W2338571857 cites W1990455420 @default.
- W2338571857 cites W1990796256 @default.
- W2338571857 cites W1991629268 @default.
- W2338571857 cites W1995704440 @default.
- W2338571857 cites W2001071466 @default.
- W2338571857 cites W2004604974 @default.
- W2338571857 cites W2006806281 @default.
- W2338571857 cites W2007002347 @default.
- W2338571857 cites W2007909824 @default.
- W2338571857 cites W2011068269 @default.
- W2338571857 cites W2014536520 @default.
- W2338571857 cites W2014779844 @default.
- W2338571857 cites W2016395055 @default.
- W2338571857 cites W2021538200 @default.
- W2338571857 cites W2021876818 @default.
- W2338571857 cites W2023202045 @default.
- W2338571857 cites W2023492107 @default.
- W2338571857 cites W2029089875 @default.
- W2338571857 cites W2031339008 @default.
- W2338571857 cites W2031411898 @default.
- W2338571857 cites W2034854030 @default.
- W2338571857 cites W2038246612 @default.
- W2338571857 cites W2050886209 @default.
- W2338571857 cites W2052823596 @default.
- W2338571857 cites W2054847598 @default.
- W2338571857 cites W2056609366 @default.
- W2338571857 cites W2062109140 @default.
- W2338571857 cites W2064780206 @default.
- W2338571857 cites W2064837694 @default.
- W2338571857 cites W2068633547 @default.
- W2338571857 cites W2072658787 @default.
- W2338571857 cites W2074777798 @default.
- W2338571857 cites W2086950114 @default.
- W2338571857 cites W2093471397 @default.
- W2338571857 cites W2106878780 @default.
- W2338571857 cites W2110634891 @default.
- W2338571857 cites W2125123295 @default.
- W2338571857 cites W2130186203 @default.
- W2338571857 cites W2141920788 @default.
- W2338571857 cites W2149715145 @default.
- W2338571857 cites W2157016784 @default.
- W2338571857 cites W2158204011 @default.
- W2338571857 cites W2161946327 @default.
- W2338571857 cites W2170966323 @default.
- W2338571857 cites W2283022630 @default.
- W2338571857 cites W2317798403 @default.
- W2338571857 cites W2317988152 @default.
- W2338571857 cites W2323147899 @default.
- W2338571857 cites W2335095506 @default.
- W2338571857 cites W4230940536 @default.
- W2338571857 cites W4254912559 @default.
- W2338571857 cites W642790846 @default.
- W2338571857 doi "https://doi.org/10.1021/acs.langmuir.5b02158" @default.
- W2338571857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26378619" @default.
- W2338571857 hasPublicationYear "2015" @default.
- W2338571857 type Work @default.
- W2338571857 sameAs 2338571857 @default.
- W2338571857 citedByCount "97" @default.
- W2338571857 countsByYear W23385718572016 @default.
- W2338571857 countsByYear W23385718572017 @default.
- W2338571857 countsByYear W23385718572018 @default.
- W2338571857 countsByYear W23385718572019 @default.
- W2338571857 countsByYear W23385718572020 @default.
- W2338571857 countsByYear W23385718572021 @default.
- W2338571857 countsByYear W23385718572022 @default.
- W2338571857 countsByYear W23385718572023 @default.
- W2338571857 crossrefType "journal-article" @default.
- W2338571857 hasAuthorship W2338571857A5013516500 @default.
- W2338571857 hasAuthorship W2338571857A5040610833 @default.
- W2338571857 hasAuthorship W2338571857A5048033242 @default.
- W2338571857 hasAuthorship W2338571857A5051147546 @default.
- W2338571857 hasAuthorship W2338571857A5051824751 @default.
- W2338571857 hasAuthorship W2338571857A5068820590 @default.
- W2338571857 hasAuthorship W2338571857A5075387837 @default.
- W2338571857 hasAuthorship W2338571857A5082409429 @default.
- W2338571857 hasConcept C12554922 @default.
- W2338571857 hasConcept C127445965 @default.
- W2338571857 hasConcept C138631740 @default.