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- W2338617466 abstract "A novel drug delivery system for the treatment of p eriodontitis was developed for site ‐specific delivery of metronidazole (MTZ) which has excellent activity against anaerobic microorganisms. The calibration cur ve for MTZ was developed in pH 6.6 phosphate buffer at 287.6 nm in the range of 2 to 14 �g/ml. MTZ films were prepared by solvent casting technique using et hyl cellulose and other copolymers in chloroform: dichloromethane (1:1) solvent with dibutyl phthalat e and PEG 400 as plasticizers. FT ‐IR and UV spectroscopic methods revealed no interaction betwe en MTZ and polymers. The films were evaluated for their thickness uniformity, folding endurance, weig ht uniformity, content uniformity, tensile strength , surface pH, and in vitro antibacterial activity. In vitro release from films was fit to different equations a nd kinetic models to reveal release kinetics. Kinetic models were studied for zero order, first ‐order equations, and Hixson ‐Crowell and Higuchi models. Formulation F2 released 99.74% of drug at the end of tenth day and was considered as best formulation. A short ‐term stability study shows that drug content decrea sed in various films and was ranging from 0.8% to 3.02%." @default.
- W2338617466 created "2016-06-24" @default.
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- W2338617466 date "2010-01-01" @default.
- W2338617466 modified "2023-09-24" @default.
- W2338617466 title "BIODEGRADABLE MONOLITHIC PERIODONTAL FILMS FOR CONTROLLED DELIVERY OF METRONIDAZOLE TO PERIODONTAL POCKET" @default.
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