FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338634061> ?p ?o ?g. }

• W2338634061 endingPage "e0153045" @default.
• W2338634061 startingPage "e0153045" @default.
• W2338634061 abstract "Bacterial vaginosis (BV) is the most common female reproductive tract infection and is associated with an increased risk of acquiring and transmitting HIV by a mechanism that is not well understood. Gamma delta (GD) T cells are essential components of the adaptive and innate immune system, are present in the female reproductive tract, and play an important role in epithelial barrier protection. GD1 cells predominate in the mucosal tissue and are important in maintaining mucosal integrity. GD2 cells predominate in peripheral blood and play a role in humoral immunity and in the immune response to pathogens. HIV infection is associated with changes in GD T cells frequencies in the periphery and in the female reproductive tract. The objective of this study is to evaluate if changes in vaginal flora occurring with BV are associated with changes in endocervical GD T cell responses, which could account for increased susceptibility to HIV. Seventeen HIV-infected (HIV+) and 17 HIV-uninfected (HIV-) pre-menopausal women underwent collection of vaginal swabs and endocervical cytobrushes. Vaginal flora was assessed using the Nugent score. GD T cells were assessed in cytobrush samples by flow cytometry. Median Nugent score was 5.0 and 41% of women had abnormal vaginal flora. In HIV uninfected women there was a negative correlation between Nugent score and cervical GD1 T cells (b for interaction = - 0.176, p<0.01); cervical GD1 T cells were higher in women with normal vaginal flora than in those with abnormal flora (45.00% vs 9.95%, p = 0.005); and cervical GD2 T cells were higher in women with abnormal flora than in those with normal flora (1.70% vs 0.35%, p = 0.023). GD T cells in the genital tract are protective (GD1) and are targets for HIV entry (GD2). The decrease in cervical GD1 and increase in GD2 T cells among women with abnormal vaginal flora predisposes women with BV to HIV acquisition. We propose to use GD T cell as markers of female genital tract vulnerability to HIV." @default.
• W2338634061 created "2016-06-24" @default.
• W2338634061 creator A5011011893 @default.
• W2338634061 creator A5024330898 @default.
• W2338634061 creator A5025834447 @default.
• W2338634061 creator A5028200056 @default.
• W2338634061 creator A5036159778 @default.
• W2338634061 creator A5042219907 @default.
• W2338634061 creator A5050254856 @default.
• W2338634061 creator A5080546814 @default.
• W2338634061 creator A5084232309 @default.
• W2338634061 date "2016-04-14" @default.
• W2338634061 modified "2023-10-01" @default.
• W2338634061 title "Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study (WIHS): A Cross Sectional Study" @default.
• W2338634061 cites W1493159751 @default.
• W2338634061 cites W1699700768 @default.
• W2338634061 cites W1919603305 @default.
• W2338634061 cites W1963641872 @default.
• W2338634061 cites W1968697332 @default.
• W2338634061 cites W1981720006 @default.
• W2338634061 cites W1995236296 @default.
• W2338634061 cites W1996894450 @default.
• W2338634061 cites W1999905308 @default.
• W2338634061 cites W2006075844 @default.
• W2338634061 cites W2008933106 @default.
• W2338634061 cites W2010096653 @default.
• W2338634061 cites W2011180576 @default.
• W2338634061 cites W2017153096 @default.
• W2338634061 cites W2026927504 @default.
• W2338634061 cites W2027378590 @default.
• W2338634061 cites W2030557640 @default.
• W2338634061 cites W2031894451 @default.
• W2338634061 cites W2057205407 @default.
• W2338634061 cites W2060716894 @default.
• W2338634061 cites W2072277660 @default.
• W2338634061 cites W2091478675 @default.
• W2338634061 cites W2099409919 @default.
• W2338634061 cites W2115797193 @default.
• W2338634061 cites W2122952609 @default.
• W2338634061 cites W2124282397 @default.
• W2338634061 cites W2129351297 @default.
• W2338634061 cites W2129571707 @default.
• W2338634061 cites W2136303292 @default.
• W2338634061 cites W2136921311 @default.
• W2338634061 cites W2140935493 @default.
• W2338634061 cites W2148376355 @default.
• W2338634061 cites W2149317992 @default.
• W2338634061 cites W2150383716 @default.
• W2338634061 cites W2163488022 @default.
• W2338634061 cites W2163754455 @default.
• W2338634061 cites W2171969497 @default.
• W2338634061 cites W2277167341 @default.
• W2338634061 doi "https://doi.org/10.1371/journal.pone.0153045" @default.
• W2338634061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4831836" @default.
• W2338634061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27078021" @default.
• W2338634061 hasPublicationYear "2016" @default.
• W2338634061 type Work @default.
• W2338634061 sameAs 2338634061 @default.
• W2338634061 citedByCount "33" @default.
• W2338634061 countsByYear W23386340612016 @default.
• W2338634061 countsByYear W23386340612017 @default.
• W2338634061 countsByYear W23386340612018 @default.
• W2338634061 countsByYear W23386340612019 @default.
• W2338634061 countsByYear W23386340612020 @default.
• W2338634061 countsByYear W23386340612021 @default.
• W2338634061 countsByYear W23386340612022 @default.
• W2338634061 countsByYear W23386340612023 @default.
• W2338634061 crossrefType "journal-article" @default.
• W2338634061 hasAuthorship W2338634061A5011011893 @default.
• W2338634061 hasAuthorship W2338634061A5024330898 @default.
• W2338634061 hasAuthorship W2338634061A5025834447 @default.
• W2338634061 hasAuthorship W2338634061A5028200056 @default.
• W2338634061 hasAuthorship W2338634061A5036159778 @default.
• W2338634061 hasAuthorship W2338634061A5042219907 @default.
• W2338634061 hasAuthorship W2338634061A5050254856 @default.
• W2338634061 hasAuthorship W2338634061A5080546814 @default.
• W2338634061 hasAuthorship W2338634061A5084232309 @default.
• W2338634061 hasBestOaLocation W23386340611 @default.
• W2338634061 hasConcept C126322002 @default.
• W2338634061 hasConcept C203014093 @default.
• W2338634061 hasConcept C2777744392 @default.
• W2338634061 hasConcept C2777831542 @default.
• W2338634061 hasConcept C2779952448 @default.
• W2338634061 hasConcept C29456083 @default.
• W2338634061 hasConcept C2992003382 @default.
• W2338634061 hasConcept C42407357 @default.
• W2338634061 hasConcept C54355233 @default.
• W2338634061 hasConcept C71924100 @default.
• W2338634061 hasConcept C86803240 @default.
• W2338634061 hasConcept C8891405 @default.
• W2338634061 hasConceptScore W2338634061C126322002 @default.
• W2338634061 hasConceptScore W2338634061C203014093 @default.
• W2338634061 hasConceptScore W2338634061C2777744392 @default.
• W2338634061 hasConceptScore W2338634061C2777831542 @default.
• W2338634061 hasConceptScore W2338634061C2779952448 @default.
• W2338634061 hasConceptScore W2338634061C29456083 @default.
• W2338634061 hasConceptScore W2338634061C2992003382 @default.
• W2338634061 hasConceptScore W2338634061C42407357 @default.

• next