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- W2338753827 abstract "Abstract Oil-elicited rabbit macrophages stimulated by endotoxin were found to release increased amounts of interleukin 1 (IL-1) when incubated with silica. The assays used to determine the amount of IL-1 released were uptake of thymidine by mouse thymocytes, fever in rabbits, and neutrophilia in rats. All three assays showed that endotoxin-stimulated macrophages released five to 10 times more IL-1 when incubated with silica. Most of the IL-1 had a molecular weight (MW) of about 14,000 with a smaller amount at a MW of approximately 35,000. All of the neutrophilia-producing activity had an isoelectric point (pl) near 7. Thymocyte proliferation was promoted about equally by activities near pH 5 and 7. Fever was found not only at these two isoelectric points but also at a pl above 8 which had neither of the other two activities." @default.
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- W2338753827 date "1986-02-01" @default.
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- W2338753827 title "Release of Interleukin-1 (IL-1) and IL-1-Like Factors From Rabbit Macrophages With Silica" @default.
- W2338753827 doi "https://doi.org/10.1002/jlb.39.2.123" @default.
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