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- W2338823626 abstract "[Purpose] Hepatitis E virus infection is an important communicable disease in Asia and mainland China. The infection is characterized by the appearance of cholestatic jaundice and a high fatality among pregnant women. No outbreaks of the infection have yet been recorded in Taiwan. To ascertain the likelihood of HEV infection and its routes of transmission in Taiwan, the present study used a newly developed enzyme immunoassay to detect HEV specific neutralizing antibodies (anti-HEVne) in serum in order to assess the prevalence of hepatitis E virus infection. [Materials and Method] A series of ORF2 (open reading frame 2) with high specificity to anti-HEVne, aa578-aa607, was used as a reagent to test antibodies. The subjects tested were divided into 4 age groups: 4-5 years (200 persons, average age 4.4 years), 20-40 years (250 persons average age 32.5 years), 40-60 years 300 persons, average age 53.1 years), 60-80 years 300 persons, average age 71.9 years), and 300 pregnant women, (average age 33 years). [Results] The newly developed anti-HEVne assay as found to be very specific for the testing of HEV infection. The anti-HEV positive rates in the different age groups were, 2% (5-6 years), 8% (20-40years), 13% (40-60 years), and 11% (60-80 years). The antibody was present in about 6% of pregnant women. The findings suggested that HEV infection was higher in the 40-60 age group. According to this study, the average infection rate of the population was found to be 8.9%. [Discussion] The present study used a newly developed method to detect anti-HEV positive rates in the sera of the general population. In general, positive rates were higher in the older age groups. However, since anti-HEVne gradually disappears several years after infection, whether elderly people were more likely to be re-infected remains to be studied further." @default.
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- W2338823626 date "2001-12-01" @default.
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- W2338823626 title "Hepatitis E Virus Infection in Taiwan: Prevalence of Neurtralizing Anti-HEVne Positive Serum" @default.
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