FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338827971> ?p ?o ?g. }

• W2338827971 endingPage "3625" @default.
• W2338827971 startingPage "3617" @default.
• W2338827971 abstract "ABSTRACT Ceftaroline fosamil (CPT-F) is currently approved for use for the treatment of complicated skin and soft tissue infections and community-acquired pneumonia at 600 mg twice daily (q12h), but other dosing regimens are under evaluation. To date, very limited data on the soft tissue pharmacokinetics (PK) of the active compound, ceftaroline (CPT), are available. CPT concentrations in the plasma, muscle, and subcutis of 12 male healthy volunteers were measured by microdialysis after single and repeated intravenous administration of 600 mg CPT-F q12h or three times daily (q8h) in two groups of 6 subjects each. Relevant PK and PK/pharmacodynamic (PD) parameters were calculated and compared between groups. In plasma, the area under the concentration-time curve (AUC) from 0 to 24 h for total CPT and the cumulative percentage of the dosing interval during which the free drug concentrations exceeded the MIC ( fT MIC ) for unbound CPT for the currently established threshold of 1 mg/liter were significantly higher in the group receiving CPT-F q8h. Exposure to free drug in soft tissues was higher in the group receiving CPT-F q8h, but high interindividual variability in relevant PK parameters was observed. The mean ratios of the AUC from time zero to the end of the dosing interval (AUC 0-τ ) for free CPT in soft tissues and the AUC 0-τ for the calculated free fraction in plasma at steady state ranged from 0.66 to 0.75. Administration of CPT-F q8h led to higher levels of drug exposure in all investigated compartments. When MIC values above 1 mg/liter were assumed, the calculated fT MIC after dosing q12h was markedly lower than that after dosing q8h. The clinical implications of these differences are discussed in light of recently completed clinical phase III and PK/PD studies." @default.
• W2338827971 created "2016-06-24" @default.
• W2338827971 creator A5001644465 @default.
• W2338827971 creator A5042620178 @default.
• W2338827971 creator A5044804385 @default.
• W2338827971 creator A5055760424 @default.
• W2338827971 creator A5078556616 @default.
• W2338827971 creator A5090967143 @default.
• W2338827971 date "2016-06-01" @default.
• W2338827971 modified "2023-09-26" @default.
• W2338827971 title "Single- and Repeated-Dose Pharmacokinetics of Ceftaroline in Plasma and Soft Tissues of Healthy Volunteers for Two Different Dosing Regimens of Ceftaroline Fosamil" @default.
• W2338827971 cites W1864525092 @default.
• W2338827971 cites W1968960893 @default.
• W2338827971 cites W1974482757 @default.
• W2338827971 cites W1989484851 @default.
• W2338827971 cites W1991713678 @default.
• W2338827971 cites W2004627090 @default.
• W2338827971 cites W2011299576 @default.
• W2338827971 cites W2015652530 @default.
• W2338827971 cites W2038708693 @default.
• W2338827971 cites W2064710851 @default.
• W2338827971 cites W2081109135 @default.
• W2338827971 cites W2082251851 @default.
• W2338827971 cites W2100849301 @default.
• W2338827971 cites W2106113640 @default.
• W2338827971 cites W2114827863 @default.
• W2338827971 cites W2127345419 @default.
• W2338827971 cites W2131171455 @default.
• W2338827971 cites W2149362635 @default.
• W2338827971 cites W2155982642 @default.
• W2338827971 cites W2160238480 @default.
• W2338827971 cites W2161279982 @default.
• W2338827971 cites W2276128935 @default.
• W2338827971 cites W2324632958 @default.
• W2338827971 cites W2516738638 @default.
• W2338827971 cites W2916433178 @default.
• W2338827971 cites W4229738864 @default.
• W2338827971 cites W4232707487 @default.
• W2338827971 cites W4237533259 @default.
• W2338827971 doi "https://doi.org/10.1128/aac.00097-16" @default.
• W2338827971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4879389" @default.
• W2338827971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27044549" @default.
• W2338827971 hasPublicationYear "2016" @default.
• W2338827971 type Work @default.
• W2338827971 sameAs 2338827971 @default.
• W2338827971 citedByCount "30" @default.
• W2338827971 countsByYear W23388279712016 @default.
• W2338827971 countsByYear W23388279712017 @default.
• W2338827971 countsByYear W23388279712018 @default.
• W2338827971 countsByYear W23388279712019 @default.
• W2338827971 countsByYear W23388279712020 @default.
• W2338827971 countsByYear W23388279712021 @default.
• W2338827971 countsByYear W23388279712022 @default.
• W2338827971 countsByYear W23388279712023 @default.
• W2338827971 crossrefType "journal-article" @default.
• W2338827971 hasAuthorship W2338827971A5001644465 @default.
• W2338827971 hasAuthorship W2338827971A5042620178 @default.
• W2338827971 hasAuthorship W2338827971A5044804385 @default.
• W2338827971 hasAuthorship W2338827971A5055760424 @default.
• W2338827971 hasAuthorship W2338827971A5078556616 @default.
• W2338827971 hasAuthorship W2338827971A5090967143 @default.
• W2338827971 hasBestOaLocation W23388279711 @default.
• W2338827971 hasConcept C111113717 @default.
• W2338827971 hasConcept C112705442 @default.
• W2338827971 hasConcept C126322002 @default.
• W2338827971 hasConcept C2777288759 @default.
• W2338827971 hasConcept C44249647 @default.
• W2338827971 hasConcept C50156730 @default.
• W2338827971 hasConcept C529278444 @default.
• W2338827971 hasConcept C71924100 @default.
• W2338827971 hasConcept C76318530 @default.
• W2338827971 hasConcept C98274493 @default.
• W2338827971 hasConceptScore W2338827971C111113717 @default.
• W2338827971 hasConceptScore W2338827971C112705442 @default.
• W2338827971 hasConceptScore W2338827971C126322002 @default.
• W2338827971 hasConceptScore W2338827971C2777288759 @default.
• W2338827971 hasConceptScore W2338827971C44249647 @default.
• W2338827971 hasConceptScore W2338827971C50156730 @default.
• W2338827971 hasConceptScore W2338827971C529278444 @default.
• W2338827971 hasConceptScore W2338827971C71924100 @default.
• W2338827971 hasConceptScore W2338827971C76318530 @default.
• W2338827971 hasConceptScore W2338827971C98274493 @default.
• W2338827971 hasIssue "6" @default.
• W2338827971 hasLocation W23388279711 @default.
• W2338827971 hasLocation W23388279712 @default.
• W2338827971 hasLocation W23388279713 @default.
• W2338827971 hasLocation W23388279714 @default.
• W2338827971 hasOpenAccess W2338827971 @default.
• W2338827971 hasPrimaryLocation W23388279711 @default.
• W2338827971 hasRelatedWork W2011809647 @default.
• W2338827971 hasRelatedWork W2014165224 @default.
• W2338827971 hasRelatedWork W2021319218 @default.
• W2338827971 hasRelatedWork W2066320494 @default.
• W2338827971 hasRelatedWork W2142080078 @default.
• W2338827971 hasRelatedWork W2227061539 @default.
• W2338827971 hasRelatedWork W2338827971 @default.
• W2338827971 hasRelatedWork W3021369409 @default.
• W2338827971 hasRelatedWork W3174177415 @default.

• next