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• W2338832595 abstract "Event Abstract Back to Event Study on the rapamycin release from a PLGA layer on biodegradable Mg-based drug-eluting stents Guangyin Yuan1, Yongjuan Shi1 and Jia Pei1 1 Shanghai Jiao Tong University, School of Materials Science & Engineering, China A magnesium-based alloy (Mg alloy), which is known to be biodegradable and biocompatible, has been considered as a potential material for the next-generation drug-eluting stents (DESs)[1],[2]. In this study, the interactions among Mg-Nd-Zn-Zr alloy, rapamycin and drug carrier PLGA were studied. The effect of a rapamycin- containing poly(lactic-co-glycolic acid) (PLGA) layer on the degradation properties of Mg alloy was examined. Mg can react with water to produce Mg2+, hydrogen (H2) and OH-. An in vitro hydrogen evolution test showed that a PLGA coating provided short-term protection of the Mg alloy substrate and reduced its degradation rate. The degradation of the Mg alloy deteriorated the stability of rapamycin, as the increased pH accelerated hydrolysis of rapamycin. In vitro drug release in phosphate buffered saline with 0.5% Tween 20 (PBST) showed that degradation of Mg alloy accelerated the rate of drug release from the PLGA layer, as compared with that ofthe PLGA layer on a stainless steel substrate. Our study collectively suggests that hydrogen produced from Mg alloy degradation played a significant role in the accelerated rapamycin release, while the effect of pH increase of the release medium was unobvious. This work was supported by the Science and Technology Commission of Shanghai Municipality (No. 14DZ1940800) ,ChinaReferences:[1] M. Haude, R. Erbel, P. Erne, S. Verheye, H. Degen, D. Böse, P. Vermeersch, I. Wijnbergen, N. Weissman, F. Prati, R. Waksman, J. Koolen, Safety and performance of the drug-eluting absorbable metal scaffold (DREAMS) in patients with de-novo coronary lesions: 12 month results of the prospective, multicentre, first-in-man BIOSOLVE-I trial, The Lancet. 381(2013) 836-844.[2] M. Haude, R. Erbel, P. Erne, S. Verheye, P. Vermeersch, H. Degen, D. Böse, R. Waksman, N.J. Weissmann, F. Prati, J. Koolen, CRT-715 Long Term Clinical Data Of The BIOSOLVE-I Study With The Paclitaxel-eluting Absorbable Magnesium Scaffold (DREAMS) And Multi-modality Imaging Analysis, JACC: Cardiovascular Interventions. 8(2015) S2-S3. Keywords: drug, corrosion, Surface modification, Biodegradable metal Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biomaterials for cardiovascular applications, vascular grafts and embolic devices Citation: Yuan G, Shi Y and Pei J (2016). Study on the rapamycin release from a PLGA layer on biodegradable Mg-based drug-eluting stents. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01218 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Guangyin Yuan Yongjuan Shi Jia Pei Google Guangyin Yuan Yongjuan Shi Jia Pei Google Scholar Guangyin Yuan Yongjuan Shi Jia Pei PubMed Guangyin Yuan Yongjuan Shi Jia Pei Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2338832595 date "2016-01-01" @default.
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• W2338832595 title "Study on the rapamycin release from a PLGA layer on biodegradable Mg-based drug-eluting stents" @default.
• W2338832595 doi "https://doi.org/10.3389/conf.fbioe.2016.01.01218" @default.
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