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• W2338844124 abstract "<h3>Objective</h3> As pathogen sensors, Toll-like receptors (TLR) play a role in the first defence line during HCV infection. However, the impact of the DNA sensor TLR9 on the natural course of HCV infection is unknown. To address this, <i>TLR9</i> promoter polymorphisms (single nucleotide polymorphisms (SNPs)) rs187084 and rs5743836 were investigated for their effect on disease progression. <h3>Design</h3> Therefore, the <i>TLR9</i> SNPs and the <i>interferon lambda 4</i> (<i>IFNL4</i>) rs12979860 were genotyped in chronically HCV type 1 infected (n=333), in patients who spontaneously cleared the infection (n=161), in the Swiss HCV cohort (n=1057) and the well-characterised German (n=305) and Irish (n=198) ‘anti-D’ cohorts. Functional analyses were done with promoter reporter constructs of human <i>TLR9</i> in B cells and assessing <i>TLR9</i> mRNA levels in whole blood of healthy volunteers. <h3>Results</h3> The <i>TLR9</i> rs187084 C allele was associated with spontaneous virus clearance in women of the study cohort (OR=2.15 (95% CI 1.18 to 3.90) p=0.012), of the Swiss HCV cohort (OR=2.06 (95% CI 1.02 to 4.18) p=0.044) and in both ‘anti-D’ cohorts (German: OR=2.01 (95% CI 1.14 to 3.55) p=0.016; Irish: OR=1.93 (95% CI 1.10 to 3.68) p=0.047). Multivariate analysis in the combined study and Swiss HCV cohorts supported the results (OR=1.99 (95% CI 1.30 to 3.05) p=0.002). Functional analyses revealed higher transcriptional activities for both <i>TLR9</i> variants and an association of the C allele of rs5743836 with allele-specific <i>TLR9</i> mRNA regulation by oestrogens in women. <h3>Conclusions</h3> <i>TLR9</i> promoter SNPs are associated with the natural course of HCV infection and show higher transcriptional activities. Our results imply the DNA sensor TLR9 in natural immunity against the RNA virus, HCV." @default.
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• W2338844124 date "2016-04-21" @default.
• W2338844124 modified "2023-09-27" @default.
• W2338844124 title "Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection" @default.
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• W2338844124 cites W1989993996 @default.
• W2338844124 cites W1992112231 @default.
• W2338844124 cites W1993009549 @default.
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• W2338844124 cites W2026101939 @default.
• W2338844124 cites W2026824186 @default.
• W2338844124 cites W2032783993 @default.
• W2338844124 cites W2032793008 @default.
• W2338844124 cites W2042732565 @default.
• W2338844124 cites W2043652943 @default.
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• W2338844124 cites W2063285149 @default.
• W2338844124 cites W2072154218 @default.
• W2338844124 cites W2078598043 @default.
• W2338844124 cites W2080813308 @default.
• W2338844124 cites W2085614123 @default.
• W2338844124 cites W2086409213 @default.
• W2338844124 cites W2086414517 @default.
• W2338844124 cites W2092939466 @default.
• W2338844124 cites W2095004085 @default.
• W2338844124 cites W2100994154 @default.
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• W2338844124 cites W2130775443 @default.
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• W2338844124 doi "https://doi.org/10.1136/gutjnl-2015-310239" @default.
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• W2338844124 hasPublicationYear "2016" @default.
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