Matches in SemOpenAlex for { <https://semopenalex.org/work/W2338852046> ?p ?o ?g. }
- W2338852046 abstract "The biology of atypical hemolytic uremic syndrome has been shown to involve inability to limit activation of the alternative complement pathway, with subsequent damage to systemic endothelial beds and the vasculature, resulting in the prototypic findings of a thrombotic microangiopathy. Central to this process is the formation of the terminal membrane attack complex C5b-9. Recently, application of a monoclonal antibody that specifically binds to C5, eculizumab, became available to treat patients with atypical hemolytic uremic syndrome, replacing plasma exchange or infusion as primary therapy. This review focuses on the evidence, based on published clinical trials, case series, and case reports, on the efficacy and safety of this approach." @default.
- W2338852046 created "2016-06-24" @default.
- W2338852046 creator A5016838436 @default.
- W2338852046 creator A5046005250 @default.
- W2338852046 date "2016-04-01" @default.
- W2338852046 modified "2023-10-02" @default.
- W2338852046 title "Critical appraisal of eculizumab for atypical hemolytic uremic syndrome" @default.
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