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- W2338888013 abstract "Over 60 macrocyclic bis-bibenzyls have been isolated from hepatics. They possess various biological activities such as antimicrobial, antifungal, muscle relaxant and antitumor activities, as well as inhibitory activity against DNA polymerase β and HIV. To explore the feasibility of obtaining novel bis-bibenzyls through laboratory culture, in this study, we compare the qualitative and quantitative contents of axenically farmed and field-collected specimens of Marchantia polymorpha subsp. ruderalis (Mpr). We analyzed methanol extracts of Mpr by LC–MS, and confirmed the identity of isolable compounds by NMR. We found that extracts from natural populations of Mpr contained the known bis-bibenzyl marchantin A as a major component, while the minor components do not correspond to other known bis-bibenzyls. In contrast, the chromatograms of axenically farmed Mpr extracts were highly complex, containing numerous UV active compounds. The only similarity between natural and farmed populations of Mpr was the presence of marchantin A. In the farmed Mpr production of marchantin E, G and/or C, and dehydromarchantin A is suggested. Thus, the axenically farmed liverworts produce numerous metabolites not seen in natural populations, opening up the possibility of directing biosynthesis to either increase production of known compounds or generate new compounds through non-natural precursor feeding." @default.
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- W2338888013 date "2016-05-19" @default.
- W2338888013 modified "2023-09-28" @default.
- W2338888013 title "Production of the macrocyclic bis-bibenzyls in axenically farmed and wild liverwort <b><i>Marchantia polymorpha</i></b> L. subsp. <b><i>ruderalis</i></b> Bischl. <b><i>et</i></b> Boisselier" @default.
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- W2338888013 doi "https://doi.org/10.1080/11263504.2016.1179692" @default.
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