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• W2338894911 abstract "Conventional craniofacial reconstruction methods still fail to mimic the complex 3D anatomy and biology of native tissues. Bioprinting can aid in the production of cell-incorporated and patient-tailored bioactive scaffolds that can be used for craniofacial reconstruction. Currently, there are three different bioprinting technologies (laser-assisted, inkjet, and extrusion-based) used to print craniofacial tissues. Bioprinting technologies will soon be used to enhance the self-repair capabilities of tissues in the craniofacial area. Recent developments in craniofacial reconstruction have shown important advances in both the materials and methods used. While autogenous tissue is still considered to be the gold standard for these reconstructions, the harvesting procedure remains tedious and in many cases causes significant donor site morbidity. These limitations have subsequently led to the development of less invasive techniques such as 3D bioprinting that could offer possibilities to manufacture patient-tailored bioactive tissue constructs for craniofacial reconstruction. Here, we discuss the current technological and (pre)clinical advances of 3D bioprinting for use in craniofacial reconstruction and highlight the challenges that need to be addressed in the coming years. Recent developments in craniofacial reconstruction have shown important advances in both the materials and methods used. While autogenous tissue is still considered to be the gold standard for these reconstructions, the harvesting procedure remains tedious and in many cases causes significant donor site morbidity. These limitations have subsequently led to the development of less invasive techniques such as 3D bioprinting that could offer possibilities to manufacture patient-tailored bioactive tissue constructs for craniofacial reconstruction. Here, we discuss the current technological and (pre)clinical advances of 3D bioprinting for use in craniofacial reconstruction and highlight the challenges that need to be addressed in the coming years. a graft obtained from a donor of the same species. tough layers of dense fibrous tissue that attaches muscles to other muscles or bone. a tissue graft obtained from the same patient. a thin fibrous tissue that separates a layer of cells from the underlying tissue (found, for example, in the skin and blood vessels). a scaffold or lattice structure with integrated biological function that provides an information-rich support material for tissue engineering. a cartridge filled with a liquid cell suspension used for bioprinting. also referred to as 3D bioprinting, encompasses a range of different printing technologies that deposit cells and/or biological materials that are used to manufacture 3D tissue structures. an engineered device that mimics a biologically active environment. a traumatic fracture of the floor of the eye socket typically resulting from the impact of a blunt object (e.g., a ball). a persistent opening in the roof (palate) of the mouth due to failure of fusion during embryological development. a chemical process that induces a change in the physical properties of a polymer (e.g., from soft to hard). a thin layer of cells (endothelial cells) that line the inner surface of blood and lymphatic vessels. the outermost layers of cells in the skin. a water-based gel suspended with natural or synthetic-based polymers. facial muscles that control facial expression and chewing, respectively. a 3D structure that supports tissue formation. the use of a combination of cells, engineering materials, and suitable biochemical factors to improve or replace biological function." @default.
• W2338894911 created "2016-06-24" @default.
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• W2338894911 date "2016-09-01" @default.
• W2338894911 modified "2023-10-14" @default.
• W2338894911 title "Advances in Bioprinting Technologies for Craniofacial Reconstruction" @default.
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• W2338894911 doi "https://doi.org/10.1016/j.tibtech.2016.04.001" @default.
• W2338894911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27113634" @default.
• W2338894911 hasPublicationYear "2016" @default.
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