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- W2338954311 abstract "Neoadjuvant chemotherapy has the advantage of converting unresectable breast tumors to resectable tumors and allowing more conservative surgery in some mastectomy candidates. Chemotherapy agents, including taxanes, which are recommended in the adjuvant setting, are also considered in the neoadjuvant setting. Here, we review studies of nab-paclitaxel as a neoadjuvant treatment for patients with breast cancer. PubMed and conference or congress proceedings were searched for clinical studies of nab-paclitaxel in the neoadjuvant treatment of breast cancer. We also searched ClinicalTrials.gov for ongoing trials of nab-paclitaxel as a neoadjuvant agent in breast cancer. Twenty studies of nab-paclitaxel in the neoadjuvant setting were identified. In addition to reviewing key efficacy and safety data, we discuss how each trial assessed response, focusing on pathologic complete response and residual cancer burden scoring. Safety profiles are also reviewed. nab-Paclitaxel demonstrated antitumor activity and an acceptable safety profile in the neoadjuvant treatment of breast cancer. Ongoing and future trials will further evaluate preoperative nab-paclitaxel in breast cancer, including in combination with many novel immunological targeted therapies." @default.
- W2338954311 created "2016-06-24" @default.
- W2338954311 creator A5082509731 @default.
- W2338954311 creator A5088814426 @default.
- W2338954311 date "2016-04-01" @default.
- W2338954311 modified "2023-09-27" @default.
- W2338954311 title "Neoadjuvant nab-paclitaxel in the treatment of breast cancer" @default.
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- W2338954311 doi "https://doi.org/10.1007/s10549-016-3778-z" @default.
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