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- W2338963903 abstract "SUMMARY Nine children treated for acute leukemia or lymphosarcoma developed subacute encephalopathy starting with listlessness, depression and impairment of speech. Walkingdifficulties, ataxia, spasticity and sphincter disorders developed later. Transient intracranialhypertension andabnormal movements respectivelydeveloped intwo patients. EEG frontal slow waves, raised CSFprotein, abnormalwhite matter radioisotope uptake and CT scan hypodensity with patchy contrast enhancement were evident at the onset. Later, dilated ventricles andcalcification appeared in the younger patients. Post-mortem neuropathological studies of threepatients disclosed predominantly perivascular myelin loss in areas of white matter necrosis,abnormalitiesofsmallvessels and numerous axonalswellings. The spinal cordshowed secondarydegenerationofthecorticospinal tracts. Analysisoftheaetiological factorsin thisseries pointstothe prevailing dangerofcranial radiotherapy, probably increased by the young age of patientsandbyassociated drug administration." @default.
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- W2338963903 date "1984-01-01" @default.
- W2338963903 modified "2023-09-23" @default.
- W2338963903 title "Necrotising leukoencephalopathy complicating" @default.
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