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- W2338996816 abstract "Objective To observe the desperate state of pregnant mice in forced swimming test(FST)and detect the expression of estrogen receptor α(ERα)in the hippocampus of mice after swimming,and to study the relationship between the desperate state of pregnant mice in FST and the expression of ERα in hippocampus.Methods Female Kunming mice of the same batch included 28 pregnant mice and 20 control mice.FST was repeated for 6 times,and immobility durations in the second and the sixth FST were recorded.After FST,the cerebrum was sampled,and the hippocampus was the center of paraffin-embedded section.The expression of ERα was detected by immunohistochemistry.Results The immobility durations in the second and the sixth FST were significantly longer in preganant mice than in control mice(149.21±56.10 vs 118.80±52.72 s,P =0.024;178.54±35.54 vs 150.15±37.92 s,P =0.011),respectively.ERα were expressed in the hippocampus of both pregnant mice and control mice,and the immunohistochemical score of ERα in pregnant mice was signficantly higher than that in control mice(3.86±2.69 vs 1.54±2.07,P =0.008).There were linear correlations between the immunohistochemical score and the immoblity durations in the second and sixth FST(r =0.332,P =0.021;r =0.394,P =0.006),respectively.Conclusion Pregnant mice are more likely to show desperation in FST,and the up-regulated expression of ERα in the hippocampus of pregnant mice may relate to antepartum depression." @default.
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- W2338996816 date "2010-01-01" @default.
- W2338996816 modified "2023-09-23" @default.
- W2338996816 title "Relationship between the desperate state of pregnant mice in forced swimming test and the expression of estrogen receptor alpha in hippocampus." @default.
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