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• W2339021488 abstract "Background and purpose: Bombesin shows very high-affinity for the Gasterin releasing peptide (GRP) receptors which are over expressed in different human tumors such as breast and prostate. The aim of this study was to identify a new bombesin derivative labeled with 99m Tc via HYNIC that might be used as a noninvasive tool for diagnosis of GRP receptor expressing tumors. Materials and methods: Prepared bombein derivatives were radiolabeled with 99m Tc at 100 °C for 10 min by exchange method and radiochemical analysis was performed using ITLC and HPLC methods. The stability of radiopeptide was checked in the presence of human serum at 37 °C and saline for up to 24 h. Results: ( 99m Tc-EDDA/tricin/HYNIC-(Ser)3-D-Phe 13 )BN(7-14) and ( 99m Tc-EDDA/tricin/ HYNIC-(Gly)3-D-Phe 13 )BN (7-14) were obtained with radiochemical purities of >95%. Results of in- vitro studies demonstrated a high stability in serum and saline. Conclusion: Radiolabeling of this novel conjugates with 99m Tc were easily performed using exchange labeling. The prepared 99m Tc-HYNIC-BN conjugates demonstrated some potential as site- directed diagnostic radiopharmaceuticals. Therefore, more in vivo studies are required." @default.
• W2339021488 created "2016-06-24" @default.
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• W2339021488 date "2015-10-10" @default.
• W2339021488 modified "2023-09-26" @default.
• W2339021488 title "Radiochemical Evaluation of New 99mTc-labelled Bombesin Derivatives with Tripeptidic (Ser- Ser - Ser) and (Gly-Gly-Gly) Spacer for Targeting GRP Receptor Positive-tumors" @default.
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