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- W2339022224 abstract "Anti-ulcer potential and proton pump inhibitory activity of kolaviron (KV) isolated from Garcinia kola Heckel has been evaluated using different ulcer models. Cold-restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models were used to assess anti-ulcerogenic activity of KV in rats. Effects of KV on gastric juice for free and total acidity, peptic activity and mucin secretion were also evaluated. The H + , K + -ATPase activity was assayed in gastric microsomes, spectrophotometrically. Results of this study showed that KV (200 mg/kg) reduced the incidence of ulcers in CRU (69.0%), PL (67.6%), ASP (68.6%) and AL (51.5%). Reductions were also observed in free acidity (32.6%), total acidity (56.2%) and peptic activity (35.4%) with increase in mucin secretion by 40.1%. KV inhibited the H + ,K + ATPase activity with IC 50 of 43.8 µg/ml compared with omeprazole with IC 50 of 32.3 µg/ml. KV showed both cytoprotective and anti-secretory potentials against peptic ulcer models, and a proton pump inhibitory activity. KV may emerge as a potent anti-ulcer compound." @default.
- W2339022224 created "2016-06-24" @default.
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- W2339022224 date "2011-01-22" @default.
- W2339022224 modified "2023-10-04" @default.
- W2339022224 title "Anti-ulcerogenic and proton pump (H + , K + ATPase) inhibitory activity of Kolaviron from Garcinia kola Heckel in rodents" @default.
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