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• W2339037884 abstract "An isotope-dilution method is described for the measurement of N tau-methylhistidine release from the perfused rat heart. We argue that release of N tau-methylhistidine is indicative of cardiac actin degradation. N tau-Methylhistidine release is compared with phenylalanine release in the presence of cycloheximide (phenylalanine release being a measure of degradation of mixed proteins). In hearts perfused with glucose plus acetate, the rate of actin degradation was increased by starvation and was not inhibited by insulin. In contrast, the rate of mixed-protein degradation was decreased by starvation and was inhibited by insulin. The fractional rate of degradation of mixed proteins in hearts from fed or starved rats was greater than that for actin. It is suggested that there are at least two pools of intracellular protein, the degradation rates of which differ in terms of their response to insulin and starvation." @default.
• W2339037884 created "2016-06-24" @default.
• W2339037884 creator A5054676735 @default.
• W2339037884 creator A5083682224 @default.
• W2339037884 date "1986-07-15" @default.
• W2339037884 modified "2023-09-27" @default.
• W2339037884 title "Contrasting response of protein degradation to starvation and insulin as measured by release of <i>N</i>τ-methylhistidine or phenylalanine from the perfused rat heart" @default.
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• W2339037884 doi "https://doi.org/10.1042/bj2370391" @default.
• W2339037884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1146998" @default.
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