FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339058266> ?p ?o ?g. }

• W2339058266 endingPage "565" @default.
• W2339058266 startingPage "555" @default.
• W2339058266 abstract "Glucose output from perfused livers of 48 h-starved rats was stimulated by phenylephrine (2 microM) when lactate, pyruvate, alanine, glycerol, sorbitol, dihydroxyacetone or fructose were used as gluconeogenic precursors. Phenylephrine-induced increases in glucose output were immediately preceded by a transient efflux of Ca2+ and a sustained increase in oxygen uptake. Phenylephrine decreased the perfusate [lactate]/[pyruvate] ratio when sorbitol or glycerol was present, but increased the ratio when alanine, dihydroxyacetone or fructose was present. Phenylephrine induced a rapid increase in the perfusate [beta-hydroxybutyrate]/[acetoacetate] ratio and increased total ketone-body output by 40-50% with all substrates. The oxidation of [1-14C]octanoate or 2-oxo[1-14C]glutarate to 14CO2 was increased by up to 200% by phenylephrine. All responses to phenylephrine infusion were diminished after depletion of the hepatic alpha-agonist-sensitive pool of Ca2+ and returned toward maximal responses after Ca2+ re-addition. Phenylephrine-induced increases in glucose output from lactate, sorbitol and glycerol were inhibited by the transaminase inhibitor amino-oxyacetate by 95%, 75% and 66% respectively. Data presented suggest that the mobilization of an intracellular pool of Ca2+ is involved in the activation of gluconeogenesis by alpha-adrenergic agonists in perfused rat liver. alpha-Adrenergic activation of gluconeogenesis is apparently accompanied by increases in fatty acid oxidation and tricarboxylic acid-cycle flux. An enhanced transfer of reducing equivalents from the cytoplasmic to the mitochondrial compartment may also be involved in the stimulation of glucose output from the relatively reduced substrates glycerol and sorbitol and may arise principally from an increased flux through the malate-aspartate shuttle." @default.
• W2339058266 created "2016-06-24" @default.
• W2339058266 creator A5040450395 @default.
• W2339058266 creator A5066666154 @default.
• W2339058266 creator A5073774595 @default.
• W2339058266 date "1983-06-15" @default.
• W2339058266 modified "2023-09-25" @default.
• W2339058266 title "Stimulation by α-adrenergic agonists of Ca2+ fluxes, mitochondrial oxidation and gluconeogenesis in perfused rat liver" @default.
• W2339058266 cites W121863172 @default.
• W2339058266 cites W1482090517 @default.
• W2339058266 cites W1488892368 @default.
• W2339058266 cites W1489733138 @default.
• W2339058266 cites W1556936132 @default.
• W2339058266 cites W1580153211 @default.
• W2339058266 cites W1585999638 @default.
• W2339058266 cites W1588593248 @default.
• W2339058266 cites W1596345646 @default.
• W2339058266 cites W1673034220 @default.
• W2339058266 cites W173391054 @default.
• W2339058266 cites W1755621340 @default.
• W2339058266 cites W1975997610 @default.
• W2339058266 cites W2002178679 @default.
• W2339058266 cites W20444207 @default.
• W2339058266 cites W2052159591 @default.
• W2339058266 cites W2062993845 @default.
• W2339058266 cites W2069395665 @default.
• W2339058266 cites W2079709825 @default.
• W2339058266 cites W2095748041 @default.
• W2339058266 cites W2128700835 @default.
• W2339058266 cites W2327184901 @default.
• W2339058266 cites W2395823489 @default.
• W2339058266 cites W2400196432 @default.
• W2339058266 cites W278342722 @default.
• W2339058266 doi "https://doi.org/10.1042/bj2120555" @default.
• W2339058266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1153129" @default.
• W2339058266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6882384" @default.
• W2339058266 hasPublicationYear "1983" @default.
• W2339058266 type Work @default.
• W2339058266 sameAs 2339058266 @default.
• W2339058266 citedByCount "62" @default.
• W2339058266 crossrefType "journal-article" @default.
• W2339058266 hasAuthorship W2339058266A5040450395 @default.
• W2339058266 hasAuthorship W2339058266A5066666154 @default.
• W2339058266 hasAuthorship W2339058266A5073774595 @default.
• W2339058266 hasBestOaLocation W23390582662 @default.
• W2339058266 hasConcept C126322002 @default.
• W2339058266 hasConcept C134018914 @default.
• W2339058266 hasConcept C185592680 @default.
• W2339058266 hasConcept C20904676 @default.
• W2339058266 hasConcept C24998067 @default.
• W2339058266 hasConcept C2776779347 @default.
• W2339058266 hasConcept C2776970464 @default.
• W2339058266 hasConcept C2777499176 @default.
• W2339058266 hasConcept C2777949327 @default.
• W2339058266 hasConcept C2777952589 @default.
• W2339058266 hasConcept C2779735320 @default.
• W2339058266 hasConcept C2780881558 @default.
• W2339058266 hasConcept C55493867 @default.
• W2339058266 hasConcept C62231903 @default.
• W2339058266 hasConcept C71924100 @default.
• W2339058266 hasConcept C84393581 @default.
• W2339058266 hasConcept C86803240 @default.
• W2339058266 hasConceptScore W2339058266C126322002 @default.
• W2339058266 hasConceptScore W2339058266C134018914 @default.
• W2339058266 hasConceptScore W2339058266C185592680 @default.
• W2339058266 hasConceptScore W2339058266C20904676 @default.
• W2339058266 hasConceptScore W2339058266C24998067 @default.
• W2339058266 hasConceptScore W2339058266C2776779347 @default.
• W2339058266 hasConceptScore W2339058266C2776970464 @default.
• W2339058266 hasConceptScore W2339058266C2777499176 @default.
• W2339058266 hasConceptScore W2339058266C2777949327 @default.
• W2339058266 hasConceptScore W2339058266C2777952589 @default.
• W2339058266 hasConceptScore W2339058266C2779735320 @default.
• W2339058266 hasConceptScore W2339058266C2780881558 @default.
• W2339058266 hasConceptScore W2339058266C55493867 @default.
• W2339058266 hasConceptScore W2339058266C62231903 @default.
• W2339058266 hasConceptScore W2339058266C71924100 @default.
• W2339058266 hasConceptScore W2339058266C84393581 @default.
• W2339058266 hasConceptScore W2339058266C86803240 @default.
• W2339058266 hasIssue "3" @default.
• W2339058266 hasLocation W23390582661 @default.
• W2339058266 hasLocation W23390582662 @default.
• W2339058266 hasLocation W23390582663 @default.
• W2339058266 hasLocation W23390582664 @default.
• W2339058266 hasOpenAccess W2339058266 @default.
• W2339058266 hasPrimaryLocation W23390582661 @default.
• W2339058266 hasRelatedWork W1988287975 @default.
• W2339058266 hasRelatedWork W2033761402 @default.
• W2339058266 hasRelatedWork W2064940611 @default.
• W2339058266 hasRelatedWork W2155097358 @default.
• W2339058266 hasRelatedWork W2156093747 @default.
• W2339058266 hasRelatedWork W2339058266 @default.
• W2339058266 hasRelatedWork W2963017100 @default.
• W2339058266 hasRelatedWork W3185211590 @default.
• W2339058266 hasRelatedWork W4246710695 @default.
• W2339058266 hasRelatedWork W4254172584 @default.
• W2339058266 hasVolume "212" @default.
• W2339058266 isParatext "false" @default.

• next