Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339162494> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2339162494 endingPage "1120" @default.
- W2339162494 startingPage "1118" @default.
- W2339162494 abstract "Objective To probe into the relationship between the antiviral effect and changes in levels of Th cytokines in the treatment of chronic hepatitis B using lamivudine combined with alpha interferon. Methods 39 patients with chronic hepatitis B and 20 healthy blood donors served as the subjects of the study.The patients were given each 100 mg of lamivudine PO,q.d.and 5 MU of IFN-α IM,q.o.d..The course of the combined treatment lasted 1 year.The healthy blood donors,acting as normal controls,were subjected to no drug treatment.Serum levels of IL-2,IFN-γ,IL-4 and IL-10 as well as HBV-DNA both of the patients and blood donors were determined with ELISA and PCR before and 1 year after the treatment of the patients,respectively.The patients were then subdivided into the effective group and the ineffective group according to HBV-DNA replication index and the situation of the conversion of HBeAg into HbeAb. Results After the combined treatment of the patients,serum levels of IL-2 and IFN-γ were significantly higher((P0.05)) while HBV-DNA level was significantly lower((P0.05)) than those before the treatment.Furthermore,serum levels of IL-2 and IFN-γ were significantly higher(P0.05),while those of IL-4 and HBV-DNA were significantly lower(P0.05) in patients of the effective group as compared with those of the ineffective group. Conclusion Lamivudine combined with alpha interferon was shown to have a striking inhibitory effect on the replication of HBV-DNA in the treatment of patients with chronic hepatitis B.In patients of the effective group after the treatment,the immune state of the body was converted from a chiefly Th2 type into a chiefly Th1 type." @default.
- W2339162494 created "2016-06-24" @default.
- W2339162494 creator A5009130440 @default.
- W2339162494 creator A5033259469 @default.
- W2339162494 creator A5037531648 @default.
- W2339162494 creator A5046694535 @default.
- W2339162494 date "2005-01-01" @default.
- W2339162494 modified "2023-09-23" @default.
- W2339162494 title "Relationship between the Antiviral Effect and Changes in Helper T(Th) Cytokine Levels in the Treatment of Chronic Hepatitis B Using Lamivudine Combined with Alpha Interferon" @default.
- W2339162494 hasPublicationYear "2005" @default.
- W2339162494 type Work @default.
- W2339162494 sameAs 2339162494 @default.
- W2339162494 citedByCount "0" @default.
- W2339162494 crossrefType "journal-article" @default.
- W2339162494 hasAuthorship W2339162494A5009130440 @default.
- W2339162494 hasAuthorship W2339162494A5033259469 @default.
- W2339162494 hasAuthorship W2339162494A5037531648 @default.
- W2339162494 hasAuthorship W2339162494A5046694535 @default.
- W2339162494 hasConcept C126322002 @default.
- W2339162494 hasConcept C159047783 @default.
- W2339162494 hasConcept C203014093 @default.
- W2339162494 hasConcept C2522874641 @default.
- W2339162494 hasConcept C2775940106 @default.
- W2339162494 hasConcept C2776178377 @default.
- W2339162494 hasConcept C2777382497 @default.
- W2339162494 hasConcept C2777410769 @default.
- W2339162494 hasConcept C2777869810 @default.
- W2339162494 hasConcept C2778690821 @default.
- W2339162494 hasConcept C2780593183 @default.
- W2339162494 hasConcept C2781228144 @default.
- W2339162494 hasConcept C2909179924 @default.
- W2339162494 hasConcept C3020491458 @default.
- W2339162494 hasConcept C71924100 @default.
- W2339162494 hasConcept C90924648 @default.
- W2339162494 hasConceptScore W2339162494C126322002 @default.
- W2339162494 hasConceptScore W2339162494C159047783 @default.
- W2339162494 hasConceptScore W2339162494C203014093 @default.
- W2339162494 hasConceptScore W2339162494C2522874641 @default.
- W2339162494 hasConceptScore W2339162494C2775940106 @default.
- W2339162494 hasConceptScore W2339162494C2776178377 @default.
- W2339162494 hasConceptScore W2339162494C2777382497 @default.
- W2339162494 hasConceptScore W2339162494C2777410769 @default.
- W2339162494 hasConceptScore W2339162494C2777869810 @default.
- W2339162494 hasConceptScore W2339162494C2778690821 @default.
- W2339162494 hasConceptScore W2339162494C2780593183 @default.
- W2339162494 hasConceptScore W2339162494C2781228144 @default.
- W2339162494 hasConceptScore W2339162494C2909179924 @default.
- W2339162494 hasConceptScore W2339162494C3020491458 @default.
- W2339162494 hasConceptScore W2339162494C71924100 @default.
- W2339162494 hasConceptScore W2339162494C90924648 @default.
- W2339162494 hasIssue "12" @default.
- W2339162494 hasLocation W23391624941 @default.
- W2339162494 hasOpenAccess W2339162494 @default.
- W2339162494 hasPrimaryLocation W23391624941 @default.
- W2339162494 hasRelatedWork W2019193900 @default.
- W2339162494 hasRelatedWork W2119652327 @default.
- W2339162494 hasRelatedWork W2152163050 @default.
- W2339162494 hasRelatedWork W2187341310 @default.
- W2339162494 hasRelatedWork W2347273927 @default.
- W2339162494 hasRelatedWork W2347332904 @default.
- W2339162494 hasRelatedWork W2347897053 @default.
- W2339162494 hasRelatedWork W2356512261 @default.
- W2339162494 hasRelatedWork W2366998476 @default.
- W2339162494 hasRelatedWork W2369728619 @default.
- W2339162494 hasRelatedWork W2373763932 @default.
- W2339162494 hasRelatedWork W2376901439 @default.
- W2339162494 hasRelatedWork W2380415903 @default.
- W2339162494 hasRelatedWork W2380696823 @default.
- W2339162494 hasRelatedWork W2384161300 @default.
- W2339162494 hasRelatedWork W2386652679 @default.
- W2339162494 hasRelatedWork W2389876866 @default.
- W2339162494 hasRelatedWork W2402727699 @default.
- W2339162494 hasRelatedWork W3031296337 @default.
- W2339162494 hasRelatedWork W3031960527 @default.
- W2339162494 hasVolume "24" @default.
- W2339162494 isParatext "false" @default.
- W2339162494 isRetracted "false" @default.
- W2339162494 magId "2339162494" @default.
- W2339162494 workType "article" @default.