FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2339259041> ?p ?o ?g. }

• W2339259041 endingPage "11824" @default.
• W2339259041 startingPage "11815" @default.
• W2339259041 abstract "MicroRNA-96 (miR-96) is an oncomiR that facilitates the development of malignant tumors by promoting growth, proliferation, and survival of cancer cells. Previous studies using high-throughput techniques have shown that miR-96 is upregulated in colorectal cancer compared to adjacent normal colorectal tissue. The aim of this study was the investigation of the potential clinical value of miR-96 as a molecular prognostic biomarker in colorectal adenocarcinoma. For this purpose, total RNA was extracted from 108 primary colorectal adenocarcinoma samples and 54 paired non-cancerous colorectal tissue specimens. After polyadenylation and reverse transcription, miR-96 molecules were determined using an in-house developed real-time quantitative PCR based on SYBR Green chemistry. Calculations were carried out with the comparative CT method, using SNORD48 as endogenous reference gene. Finally, extensive biostatistical analysis was performed and showed that miR-96 is significantly upregulated in colorectal adenocarcinoma specimens compared to their non-cancerous counterparts (p < 0.001) as well as in tumors having invaded regional lymph nodes (p = 0.009) and those of advanced TNM stage (p = 0.008). miR-96 expression is an unfavorable prognostic marker in colorectal adenocarcinoma, predicting poor disease-free and overall survival (p = 0.041 and 0.028, respectively), independently of classical clinicopathological parameters. Most importantly, miR-96 expression stratifies patients without distant metastasis (M0) at the time of diagnosis into two groups with substantially different prognosis (p = 0.040). In conclusion, high tissue levels of miR-96 are associated with advanced stages of colorectal adenocarcinoma and predict an increased risk for disease recurrence and poor overall survival, especially in patients without distant metastasis at the time of diagnosis." @default.
• W2339259041 created "2016-06-24" @default.
• W2339259041 creator A5010375921 @default.
• W2339259041 creator A5036306637 @default.
• W2339259041 creator A5067220885 @default.
• W2339259041 creator A5085601430 @default.
• W2339259041 date "2016-04-04" @default.
• W2339259041 modified "2023-10-17" @default.
• W2339259041 title "High miR-96 levels in colorectal adenocarcinoma predict poor prognosis, particularly in patients without distant metastasis at the time of initial diagnosis" @default.
• W2339259041 cites W14783117 @default.
• W2339259041 cites W1492436856 @default.
• W2339259041 cites W1944770503 @default.
• W2339259041 cites W1965861314 @default.
• W2339259041 cites W1967180140 @default.
• W2339259041 cites W1968968087 @default.
• W2339259041 cites W1969668903 @default.
• W2339259041 cites W1981989535 @default.
• W2339259041 cites W1988156822 @default.
• W2339259041 cites W1990207209 @default.
• W2339259041 cites W1993540464 @default.
• W2339259041 cites W1995057279 @default.
• W2339259041 cites W1997100218 @default.
• W2339259041 cites W1998449659 @default.
• W2339259041 cites W2001258296 @default.
• W2339259041 cites W2009452083 @default.
• W2339259041 cites W2013344284 @default.
• W2339259041 cites W2014571376 @default.
• W2339259041 cites W2016534280 @default.
• W2339259041 cites W2020218669 @default.
• W2339259041 cites W2032220606 @default.
• W2339259041 cites W2040153845 @default.
• W2339259041 cites W2041336158 @default.
• W2339259041 cites W2042735793 @default.
• W2339259041 cites W2043539979 @default.
• W2339259041 cites W2044883271 @default.
• W2339259041 cites W2057304361 @default.
• W2339259041 cites W2057582374 @default.
• W2339259041 cites W2066611312 @default.
• W2339259041 cites W2070583523 @default.
• W2339259041 cites W2107277218 @default.
• W2339259041 cites W2114015736 @default.
• W2339259041 cites W2114570899 @default.
• W2339259041 cites W2115590702 @default.
• W2339259041 cites W2124486266 @default.
• W2339259041 cites W2129835144 @default.
• W2339259041 cites W2132054434 @default.
• W2339259041 cites W2133650808 @default.
• W2339259041 cites W2134118500 @default.
• W2339259041 cites W2135007926 @default.
• W2339259041 cites W2138664009 @default.
• W2339259041 cites W2148929244 @default.
• W2339259041 cites W2150536104 @default.
• W2339259041 cites W2151868278 @default.
• W2339259041 cites W2154155138 @default.
• W2339259041 cites W2155396586 @default.
• W2339259041 cites W2155461561 @default.
• W2339259041 cites W2165245450 @default.
• W2339259041 cites W2170908852 @default.
• W2339259041 cites W2192080449 @default.
• W2339259041 doi "https://doi.org/10.1007/s13277-016-5023-0" @default.
• W2339259041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27044381" @default.
• W2339259041 hasPublicationYear "2016" @default.
• W2339259041 type Work @default.
• W2339259041 sameAs 2339259041 @default.
• W2339259041 citedByCount "41" @default.
• W2339259041 countsByYear W23392590412016 @default.
• W2339259041 countsByYear W23392590412017 @default.
• W2339259041 countsByYear W23392590412018 @default.
• W2339259041 countsByYear W23392590412019 @default.
• W2339259041 countsByYear W23392590412020 @default.
• W2339259041 countsByYear W23392590412021 @default.
• W2339259041 countsByYear W23392590412022 @default.
• W2339259041 countsByYear W23392590412023 @default.
• W2339259041 crossrefType "journal-article" @default.
• W2339259041 hasAuthorship W2339259041A5010375921 @default.
• W2339259041 hasAuthorship W2339259041A5036306637 @default.
• W2339259041 hasAuthorship W2339259041A5067220885 @default.
• W2339259041 hasAuthorship W2339259041A5085601430 @default.
• W2339259041 hasConcept C104317684 @default.
• W2339259041 hasConcept C121608353 @default.
• W2339259041 hasConcept C126322002 @default.
• W2339259041 hasConcept C142724271 @default.
• W2339259041 hasConcept C143998085 @default.
• W2339259041 hasConcept C145059251 @default.
• W2339259041 hasConcept C146357865 @default.
• W2339259041 hasConcept C151730666 @default.
• W2339259041 hasConcept C2779013556 @default.
• W2339259041 hasConcept C2781182431 @default.
• W2339259041 hasConcept C2781197716 @default.
• W2339259041 hasConcept C2909234372 @default.
• W2339259041 hasConcept C48023723 @default.
• W2339259041 hasConcept C502942594 @default.
• W2339259041 hasConcept C526805850 @default.
• W2339259041 hasConcept C55493867 @default.
• W2339259041 hasConcept C71924100 @default.
• W2339259041 hasConcept C86803240 @default.
• W2339259041 hasConceptScore W2339259041C104317684 @default.
• W2339259041 hasConceptScore W2339259041C121608353 @default.

• next